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Alpha-methyl-5-HT, a 5-HT2 receptor agonist, stimulates beta2-adrenoceptors in guinea pig airway smooth muscle

dc.creatorCampos-Bedolla, Patricia
dc.creatorVargas, Mario H.
dc.creatorCalixto, Eduardo
dc.creatorSegura, Patricia
dc.creatorMendoza-Patiño, Nicandro
dc.creatorFigueroa, Alejandra
dc.creatorFlores-Soto, Edgar
dc.creatorBarajas-López, Carlos
dc.creatorMontaño, Luis M.
dc.date.accessioned2017-06-30T01:34:24Z
dc.date.available2017-06-30T01:34:24Z
dc.date.issued2006es_ES
dc.identifier1467es_ES
dc.identifier.issn1043-6618es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6148
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2006.09.006es_ES
dc.language.isoenges_ES
dc.relation54 (6) 468-473 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAlpha-methyl-5-HT, a 5-HT2 receptor agonist, stimulates beta2-adrenoceptors in guinea pig airway smooth musclees_ES
dc.typearticlees_ES
dc.contributor.affiliationUnidad de Investigación Médica en Enfermedades Neurológicas, Instituto Mexicano del Seguro Social, México DF, Mexico.es_ES
dc.contributor.emaillmmr@servidor.unam.mxes_ES
dc.relation.jnabreviadoPHARMACOL RESes_ES
dc.relation.journalPharmacological Researches_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1096-1186es_ES
dc.identifier.doi10.1016/j.phrs.2006.09.006es_ES
dc.description.monthDices_ES
dc.description.abstractotrodioma_-Methyl-5-HT is widely used as a high-affinity 5-HT2 receptors agonist, though some studies have postulated that this drug also activates other serotonergic receptors. In the present work, we found that a wide range of concentrations of _-methyl-5-HT induced biphasic responses (contraction followed by relaxation) in guinea pig tracheal rings. The relaxing phase caused by 32 _M _-methyl-5-HT was blocked by 0.1 _M propranolol. Furthermore, during an ongoing histamine-induced contraction, _-methyl-5-HT (0.1–100 _M) produced a concentration-dependent relaxation starting at 10 _M. This relaxation was fully abolished by 0.1 _M propranolol or 1 _M ICI 118,551 (a selective _2-adrenoceptor antagonist). Additionally, in electrophysiological recordings, 32 _M _-methyl-5-HT also enhanced the membrane K+ currents of single tracheal myocytes, an effect reverted by propranolol and ICI 118,551, and mimicked by 0.1 _M salbutamol. Thus, we concluded that _-methyl-5-HT activates _2-adrenoceptors in guinea pig tracheal smooth muscle at concentrations ≥10 _M. This effect must be taken into account when this drug is used in airway smooth muscle and in other tissues expressing _2-adrenoceptorses_ES
dc.subject.koAdrenergic beta-Antagonistses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koCaffeinees_ES
dc.subject.kopharmacologyes_ES
dc.subject.koCalciumes_ES
dc.subject.kometabolismes_ES
dc.subject.koGuinea Pigses_ES
dc.subject.koKetanserines_ES
dc.subject.kopharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koMuscle, Smoothes_ES
dc.subject.kodrug effectses_ES
dc.subject.koMyocytes, Smooth Musclees_ES
dc.subject.kodrug effectses_ES
dc.subject.koPatch-Clamp Techniqueses_ES
dc.subject.koPhosphodiesterase Inhibitorses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koPropanolamineses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koPropranololes_ES
dc.subject.kopharmacologyes_ES
dc.subject.koReceptors, Adrenergic, beta-2es_ES
dc.subject.kometabolismes_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.kodrug effectses_ES
dc.subject.koSerotonines_ES
dc.subject.koanalogs & derivativeses_ES
dc.subject.koSerotonines_ES
dc.subject.kopharmacologyes_ES
dc.subject.koSerotonin Antagonistses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koSerotonin Receptor Agonistses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koTracheaes_ES
dc.subject.kodrug effectses_ES
dc.subject.koAdrenergic beta-Antagonistses_ES
dc.subject.koPhosphodiesterase Inhibitorses_ES
dc.subject.koPropanolamineses_ES
dc.subject.koReceptors, Adrenergic, beta-2es_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koSerotonin Antagonistses_ES
dc.subject.koSerotonin Receptor Agonistses_ES
dc.subject.koalpha-methylserotonines_ES
dc.subject.koSerotonines_ES
dc.subject.koPropranololes_ES
dc.subject.koCaffeinees_ES
dc.subject.koICI 118551es_ES
dc.subject.koKetanserines_ES
dc.subject.koCalciumes_ES


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