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Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice

dc.creatorMartínez, A.L.
dc.creatorDomínguez, F.
dc.creatorOrozco, S.
dc.creatorChávez, M.
dc.creatorSalgado, H.
dc.creatorGonzález, M.
dc.creatorGonzález-Trujano, M.E.
dc.date.accessioned2017-06-30T01:33:58Z
dc.date.available2017-06-30T01:33:58Z
dc.date.issued2006es_ES
dc.identifier1464es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6145
dc.identifier.urihttps://doi.org/10.1016/j.jep.2006.01.003es_ES
dc.language.isofraes_ES
dc.relation106 (2) 250-255 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleNeuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in micees_ES
dc.typearticlees_ES
dc.contributor.affiliationDirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370 México, D.F., Mexicoes_ES
dc.contributor.emailevag@imp.edu.mx ; evagontru@yahoo.com.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2006.01.003es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaMagnolia dealbata Zucc. is considered to have tranquilizer and anticonvulsant properties in Mexican traditional medicine. In the present study we report the effects of a crude extract of Magnolia dealbata (30, 100 and 300 mg-kg) on mouse central nervous system (CNS). Pharmacological effects were tested on ambulatory activity, anti-anxiety response, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced seizures in comparison to honokiol, buspirone, ethosuximide and diazepam as corresponding reference drugs. No changes in spontaneous locomotor activity were produced posterior to Magnolia dealbata administration; however, a significant and dose-dependent diminution in the anxiety response was observed in experimental models such as plus-maze, head-dipping and exploratory rearing tests. Magnolia dealbata not only prolonged the time of sodium pentobarbital-induced hypnosis and delayed the onset of PTZ-induced mioclonus and clonus, but also hindered the presence of tonic seizures and avoided mortality. The hypnotic, anxiolytic and anticonvulsant effects obtained in these experiments support the hypothesis that Magnolia dealbata possesses CNS activity and reinforces the popular use in Mexican traditional medicinees_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.kotoxicityes_ES
dc.subject.koAnticonvulsantses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnticonvulsantses_ES
dc.subject.kotoxicityes_ES
dc.subject.koDiazepames_ES
dc.subject.kopharmacologyes_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koEthanoles_ES
dc.subject.koHypnotics and Sedativeses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koHypnotics and Sedativeses_ES
dc.subject.kotoxicityes_ES
dc.subject.koLethal Dose 50es_ES
dc.subject.koMagnoliaes_ES
dc.subject.koMalees_ES
dc.subject.koMaze Learninges_ES
dc.subject.kodrug effectses_ES
dc.subject.koMicees_ES
dc.subject.koPentobarbitales_ES
dc.subject.koPentylenetetrazolees_ES
dc.subject.koPlant Extractses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koPlant Extractses_ES
dc.subject.kotoxicityes_ES
dc.subject.koPlant Leaveses_ES
dc.subject.koSeizureses_ES
dc.subject.kochemically inducedes_ES
dc.subject.koSeizureses_ES
dc.subject.koprevention & controles_ES
dc.subject.koSleepes_ES
dc.subject.kodrug effectses_ES
dc.subject.koSolventses_ES
dc.subject.koTime Factorses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koAnticonvulsantses_ES
dc.subject.koHypnotics and Sedativeses_ES
dc.subject.koPlant Extractses_ES
dc.subject.koSolventses_ES
dc.subject.koDiazepames_ES
dc.subject.koPentylenetetrazolees_ES
dc.subject.koEthanoles_ES
dc.subject.koPentobarbitales_ES


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