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A novel role for endogenous pituitary adenylate cyclase activating polypeptide in the magnocellular neuroendocrine system

dc.creatorGillard, E.R.
dc.creatorLeón-Olea, M.
dc.creatorMucio-Ramírez, S.
dc.creatorCoburn, C.G.
dc.creatorSánchez-Islas, E.
dc.creatorDe León, A.
dc.creatorMussenden, H.
dc.creatorBauce, L.G.
dc.creatorPittman, Q.J.
dc.creatorCurrás-Collazo, M.C.
dc.date.accessioned2017-06-30T01:33:15Z
dc.date.available2017-06-30T01:33:15Z
dc.date.issued2006es_ES
dc.identifier1458es_ES
dc.identifier.issn0013-7227es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6139
dc.identifier.urihttps://doi.org/10.1210/en.2005-1103es_ES
dc.language.isoenges_ES
dc.relation147 (2) 791-803 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleA novel role for endogenous pituitary adenylate cyclase activating polypeptide in the magnocellular neuroendocrine systemes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Cell Biology and Neuroscience, University of California, Riverside, 92521, USA.es_ES
dc.contributor.emailerachelgillard@yahoo.comes_ES
dc.relation.jnabreviadoENDOCRINOLOGYes_ES
dc.relation.journalEndocrinologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1945-7170es_ES
dc.identifier.doi10.1210/en.2005-1103es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaCentral release of vasopressin (VP) by the magnocellular neuroendocrine cells (MNCs) responsible for systemic VP release is believed to be important in modulating the activity of these neurons during dehydration. Central VP release from MNC somata and dendrites is stimulated by both dehydration and pituitary adenylate cyclase activating polypeptide (PACAP). Although PACAP is expressed in MNCs, its potential role in the magnocellular response to dehydration is unexplored. The current study demonstrates that prolonged dehydration increases immunoreactivity for PACAP-27, PACAP-38, and the type I PACAP receptor in the supraoptic nucleus (SON) of the rat. In addition, PACAP stimulates local VP release in the euhydrated rat SON in vitro, and this effect is reduced by the PACAP receptor antagonist PAC(6-27) (100 nm), suggesting the participation of PACAP receptors. Concomitant with its effects on local VP release, PACAP also reduces basal glutamate and aspartate release in the euhydrated rat SON. Furthermore, somatodendritic VP release elicited by acute dehydration is blocked by PAC(6-27), suggesting that endogenous PACAP participates in this response. Consistent with this, RIA revealed that local PACAP-38 release within the SON is significantly elevated during acute dehydration. These results suggest that prolonged activation of hypothalamic MNCs is accompanied by up-regulation of PACAP and the type I PACAP receptor in these cells and that somatodendritic VP release in response to acute dehydration is mediated by activation of PACAP receptors by endogenous PACAP released within the SON. A potential role for PACAP in promoting efficient, but not exhaustive, systemic release of VP from MNCs during physiological challenge is discussed.es_ES
dc.subject.koAdaptation, Physiologicales_ES
dc.subject.koAnimalses_ES
dc.subject.koDehydrationes_ES
dc.subject.kometabolismes_ES
dc.subject.koImmunohistochemistryes_ES
dc.subject.koMalees_ES
dc.subject.koNeurosecretory Systemses_ES
dc.subject.kocytologyes_ES
dc.subject.koNeurosecretory Systemses_ES
dc.subject.kometabolismes_ES
dc.subject.koPituitary Adenylate Cyclase-Activating Polypeptidees_ES
dc.subject.kometabolismes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Sprague-Dawleyes_ES
dc.subject.koReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type Ies_ES
dc.subject.kometabolismes_ES
dc.subject.koSignal Transductiones_ES
dc.subject.kophysiologyes_ES
dc.subject.koSupraoptic Nucleuses_ES
dc.subject.kocytologyes_ES
dc.subject.koSupraoptic Nucleuses_ES
dc.subject.kometabolismes_ES
dc.subject.koVasopressinses_ES
dc.subject.kosecretiones_ES
dc.subject.koWater-Electrolyte Balancees_ES
dc.subject.kophysiologyes_ES
dc.subject.koPituitary Adenylate Cyclase-Activating Polypeptidees_ES
dc.subject.koReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type Ies_ES
dc.subject.koVasopressinses_ES


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