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Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats

dc.creatorFernández-Guasti, A.
dc.creatorReyes, R.
dc.creatorMartínez-Mota, L.
dc.creatorLópez-Muñoz, F.J.
dc.date.accessioned2017-06-30T01:33:07Z
dc.date.available2017-06-30T01:33:07Z
dc.date.issued2005es_ES
dc.identifier1457es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6138
dc.identifier.urihttps://doi.org/10.1007/s00213-005-2190-xes_ES
dc.language.isoenges_ES
dc.relation180 (3) 399-407 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleInfluence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del IPN, Calz. de los Tenorios 235, Col. Granjas Coapa, Mexico, 14330, DF, Mexicoes_ES
dc.contributor.emailjfernand@mail.cinvestav.mxes_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGY (BERL)es_ES
dc.relation.journalPsychopharmacology (Berl)es_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.doi10.1007/s00213-005-2190-xes_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaRATIONALE: The effect of anxiety on nociception has been evaluated but not that of nociception on anxiety. OBJECTIVE: The study was conducted to analyse the influence of nociception on basal levels of anxiety-like behaviour and on the action of anxiolytic drugs. METHODS: Nociception was induced by an intra-articular injection of uric acid at 3.75 or 7.5%. Experimental anxiety was determined in the rat burying behaviour and the elevated plus maze tests. To separate specific anxiety-related drug actions, a spontaneous ambulatory test was included. The anxiolytics, buspirone (2.5 and 5.0 mg-kg, i.p.) and diazepam (0.5, 1.0 and 2.0 mg-kg, i.p.), were used. RESULTS: In the nociception test, the pain-induced functional impairment rat model, uric acid at 3.75 and 7.5% had an effect of around 35 and 75%, respectively. Uric acid (UA) at the lower dose (3.75%) lacked an effect on burying behaviour but significantly increased the time spent and number of entries to the open arms; the higher UA dose (7.5%) produced a significant increase in the time spent and number of entries to the open arms and a statistically significant reduction in cumulative burying. Diazepam and buspirone produced a clear dose-dependent reduction in cumulative burying. In the plus maze, diazepam also induced an increase in the time spent and number of entries to the open arms. In the burying behaviour test, rats with a mild level of nociception (uric acid at 7.5%) were insensitive to the anxiolytic-like effect of these anxiolytic drugs. In the plus maze test, the anxiolytic-like effect of diazepam (1.0 mg-kg) was blocked under both levels of nociception. CONCLUSIONS: These data demonstrate that nociception modifies the response to anxiolytic drugs. The role of factors with anxiogenic properties produced during inflammation, which may modify diazepam and buspirone effects, is discussedes_ES
dc.subject.koAnalysis of Variancees_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.kotherapeutic usees_ES
dc.subject.koAnxietyes_ES
dc.subject.kodrug therapyes_ES
dc.subject.koAnxietyes_ES
dc.subject.kophysiopathologyes_ES
dc.subject.koAspirines_ES
dc.subject.kopharmacologyes_ES
dc.subject.koBehavior, Animales_ES
dc.subject.kodrug effectses_ES
dc.subject.koBuspironees_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koBuspironees_ES
dc.subject.kotherapeutic usees_ES
dc.subject.koDiazepames_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koDiazepames_ES
dc.subject.kotherapeutic usees_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koInflammationes_ES
dc.subject.kochemically inducedes_ES
dc.subject.koInflammationes_ES
dc.subject.kophysiopathologyes_ES
dc.subject.koInjections, Intra-Articulares_ES
dc.subject.koMalees_ES
dc.subject.koMaze Learninges_ES
dc.subject.kodrug effectses_ES
dc.subject.koMotor Activityes_ES
dc.subject.kodrug effectses_ES
dc.subject.koPaines_ES
dc.subject.kochemically inducedes_ES
dc.subject.koPaines_ES
dc.subject.kophysiopathologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koUric Acides_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koBuspironees_ES
dc.subject.koDiazepames_ES
dc.subject.koAspirines_ES
dc.subject.koUric Acides_ES


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