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Isobolographic analysis of the sedative interaction between six central nervous system depressant drugs and Valeriana edulis hydroalcoholic extract in mice

dc.creatorUgalde, Martha
dc.creatorReza, Victoria
dc.creatorGonzález-Trujano, M. Eva
dc.creatorAvula, Bharathi
dc.creatorKhan, Ikhlas A.
dc.creatorNavarrete, Andrés
dc.date.accessioned2017-06-30T01:32:33Z
dc.date.available2017-06-30T01:32:33Z
dc.date.issued2005es_ES
dc.identifier1453es_ES
dc.identifier.issn0022-3573es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6134
dc.identifier.urihttps://doi.org/10.1211/0022357056000es_ES
dc.language.isoenges_ES
dc.relation57 (5) 631-639 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleIsobolographic analysis of the sedative interaction between six central nervous system depressant drugs and Valeriana edulis hydroalcoholic extract in micees_ES
dc.typearticlees_ES
dc.contributor.affiliationFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacan 04510, México D.F., Méxicoes_ES
dc.contributor.emailanavarrt@servidor.unam.mxes_ES
dc.relation.jnabreviadoJ PHARM PHARMACOLes_ES
dc.relation.journalThe Journal of Pharmacy and Pharmacologyes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2042-7158es_ES
dc.identifier.doi10.1211/0022357056000es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaIt has been declared frequently that valerian may potentiate the effect of other central nervous system (CNS) depressant drugs, however there has been a lack of experimental data. We have evaluated the profile of the interactions between the ethanol extract of Valeriana edulis spp procera and six CNS depressant drugs using an exploratory model to test the sedative effect in mice. All the compounds tested showed a dose-dependent sedative effect with the following ED50 values: valerian 181.62, diazepam 1.21, ethanol 1938, pentobarbital 11.86, buspirone 1.04, haloperidol 0.41 and diphenhydramine 17.06 mg kg-1. An isobolographic analysis was used to evaluate the sedative interaction of the intraperitoneal co-administration of 1:1 fixed-ratio combination of equi-effective doses of valerian extract with each CNS depressant drug. The ED50 theoretical (Zadd) and experimental (Zexp) for each combination were: valerian+diazepam,Zadd=91.41 mg kg-1, Zexp=81.64 mg kg-1; valerian+ethanol, Zadd=1060.22 mg kg-1, Zexp=687.89 mg kg-1; valerian+pentobarbital, Zadd=96.74 mg kg-1, Zexp=151.83 mg kg-1; valerian+buspirone, Zadd=91.33 mg kg-1, Zexp=112.73 mg kg-1; valerian+haloperidol, Zadd=91.01 mg kg-1, Zexp=91.52 mg kg-1; valerian+diphenhydramine, Zadd=99.34 mg kg-1, Zexp=123.52 mg kg-1. Neither synergistic nor attenuate effects were found in any of the combinations evaluated. We concluded that the valerian extract did not potentiate the sedative effect of commonly prescribed CNS depressant drugs as was expected. The additive effect found through the isobolographic analysis suggested that the sedative effect of V. edulis resulted from the activation of common mechanisms of haloperidol, diazepam, buspirone, pentobarbital, diphenhydramine and ethanoles_ES
dc.subject.koAnimalses_ES
dc.subject.koCentral Nervous System Depressantses_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koCentral Nervous System Depressantses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koDrug Synergismes_ES
dc.subject.koExploratory Behaviores_ES
dc.subject.kodrug effectses_ES
dc.subject.koInjections, Intraperitoneales_ES
dc.subject.koMalees_ES
dc.subject.koMicees_ES
dc.subject.koMice, Inbred ICRes_ES
dc.subject.koPlant Extractses_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koPlant Extractses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koPlant Rootses_ES
dc.subject.kochemistryes_ES
dc.subject.koTime Factorses_ES
dc.subject.koValerianes_ES
dc.subject.kochemistryes_ES
dc.subject.koCentral Nervous System Depressantses_ES
dc.subject.koPlant Extractses_ES


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