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Synaptic and extrasynaptic secretion of serotonin

dc.creatorDe-Miguel, Francisco F.
dc.creatorTrueta, Citlali
dc.date.accessioned2017-06-30T01:32:17Z
dc.date.available2017-06-30T01:32:17Z
dc.date.issued2005es_ES
dc.identifier1451es_ES
dc.identifier.issn0272-4340es_ES
dc.identifier.urihttp://link.springer.com/article/10.1007%2Fs10571-005-3061-zes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6132
dc.identifier.urihttps://doi.org/10.1007/s10571-005-3061-zes_ES
dc.language.isoenges_ES
dc.relation25 (2) 294-312 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleSynaptic and extrasynaptic secretion of serotonines_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Biofísica, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, 04510 DF, Méxicoes_ES
dc.contributor.emailffernand@ifc.unam.mxes_ES
dc.relation.jnabreviadoCELL MOL NEUROBIOLes_ES
dc.relation.journalCellular and Molecular Neurobiologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1573-6830es_ES
dc.identifier.doi10.1007/s10571-005-3061-zes_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaSerotonin is a major modulator of behavior in vertebrates and invertebrates and deficiencies in the serotonergic system account for several behavioral disorders in humans. The small numbers of serotonergic central neurons of vertebrates and invertebrates produce their effects by use of two modes of secretion: from synaptic terminals, acting locally in ‘hard wired’ circuits, and from extrasynaptic axonal and somatodendritic release sites in the absence of postsynaptic targets, producing paracrine effects. In this paper, we review the evidence of synaptic and extrasynaptic release of serotonin and the mechanisms underlying each secretion mode by combining evidence from vertebrates and invertebrates. Particular emphasis is given to somatic secretion of serotonin by central neurons. Most of the mechanisms of serotonin release have been elucidated in cultured synapses made by Retzius neurons from the central nervous system of the leech. Serotonin release from synaptic terminals occurs from clear and dense core vesicles at active zones upon depolarization. In general, synaptic serotonin release is similar to release of acetylcholine in the neuromuscular junction. The soma of Retzius neurons releases serotonin from clusters of dense core vesicles in the absence of active zones. This type of secretion is dependent of the stimulation frequency, on L-type calcium channel activation and on calcium-induced calcium release. The characteristics of somatic secretion of serotonin in Retzius neurons are similar to those of somatic secretion of dopamine and peptides by other neuron types. In general, somatic secretion by neurons is different from transmitter release from clear vesicles at synapses and similar to secretion by excitable endocrine cellses_ES
dc.subject.koAnimalses_ES
dc.subject.koExocytosises_ES
dc.subject.kophysiologyes_ES
dc.subject.koHumanses_ES
dc.subject.koNeuronses_ES
dc.subject.kometabolismes_ES
dc.subject.koNeuronses_ES
dc.subject.kosecretiones_ES
dc.subject.koSerotonines_ES
dc.subject.kometabolismes_ES
dc.subject.koSerotonines_ES
dc.subject.kosecretiones_ES
dc.subject.koSynapseses_ES
dc.subject.kometabolismes_ES
dc.subject.koSynaptic Vesicleses_ES
dc.subject.kometabolismes_ES
dc.subject.koSerotonines_ES


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