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Effects of mirtazapine on the sleep wake rhythm of geriatric patients with major depression: an exploratory study with actigraphy

dc.creatorRothschild-Fuentes, B.
dc.creatorRoche, A.
dc.creatorJiménez-Genchi, A.
dc.creatorSánchez-Ferrer, J.C.
dc.creatorFresán, A.
dc.creatorMuñoz-Delgado, J.
dc.date.accessioned2017-06-29T06:10:15Z
dc.date.available2017-06-29T06:10:15Z
dc.date.issued2012es_ES
dc.identifier717es_ES
dc.identifier.issn0176-3679es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5401
dc.identifier.urihttp://doi.org/10.1055/s-0032-1323655es_ES
dc.language.isoenges_ES
dc.relation45, 1-4 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of mirtazapine on the sleep wake rhythm of geriatric patients with major depression: an exploratory study with actigraphyes_ES
dc.typearticlees_ES
dc.contributor.affiliationServicio de Psicogeriatría, Hospital Psiquiátrico Fray Bernardino Alvarez, México, D.F., Méxicoes_ES
dc.contributor.emailmunozd@imp.edu.mxes_ES
dc.relation.jnabreviadoPHAMACOPSYCHIATRYes_ES
dc.relation.journalPharmacopsychiatryes_ES
dc.identifier.placeStuttgartes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doihttp://dx.doi.org/10.1055/s-0032-1323655es_ES
dc.description.abstractotrodiomaIntroduction: Major depression and insomnia are among the most frequent neuropsychiatric syndromes in the geriatric population. Although most SSRI antidepressants aff ect sleep continuity, mirtazapine has been found to improve sleep continuity in patients with depression. The aim of the present study was to assess by actigraphic recordings changes in sleep patterns of geriatric patients with major depression before and during treatment with mirtazapine (30 mg). Methods: Patients aged 60 years or more with major depressive disorder were recruited at the outpatient service of a specialized mental health centre. Severity of depression was rated with the Montgomery-Asberg depression rating scale and subjective perception of sleep was assessed with the Pittsburgh sleep quality index (PSQI). Actigraphic parameters were registered 4 days before the onset of mirtazapine treatment (patients were drug free in this period of time) and recorded at day 60 of treatment with mirtazapine. Results: A signifi cant decrease was observed in the sleep fragmentation index. While a significant improvement was observed in the subjective assessment of quality after treatment with mirtazapine, actigraphic measures of sleep parameters did not show changes in line with mirtazapine treatment. Discussion: Mirtazapine produces minimal changes on actigraphic measures in the sleep of elderly outpatients. Sleep produced by mirtazapine indicates a more pronounced eff ect in ≥ 80-year-old patients. This diff erential response should be considered during treatment of this clinical populationes_ES
dc.subject.kwTrastornos del sueñoes_ES
dc.subject.kwPrivación de sueñoes_ES
dc.subject.kwDepresiónes_ES
dc.subject.kwTratamiento para la depresiónes_ES
dc.subject.koSleep disturbanceses_ES
dc.subject.koSleep deprivationes_ES
dc.subject.koDepressiones_ES
dc.subject.koDepression treatmentes_ES


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