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Toluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult rats

dc.creatorHuerta-Rivas, Alejandra
dc.creatorLópez-Rubalcava, Carolina
dc.creatorSánchez-Serrano, Sinthia L.
dc.creatorValdez-Tapia, Marina
dc.creatorLamas, Mónica
dc.creatorCruz, Silvia L.
dc.date.accessioned2017-06-29T06:10:12Z
dc.date.available2017-06-29T06:10:12Z
dc.date.issued2012es_ES
dc.identifier716es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5400
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2012.03.018es_ES
dc.language.isoenges_ES
dc.relation102 (1) 48-57 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleToluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Cinvestav, Sede Sur. Calzada de los Tenorios # 235, Col. Granjas Coapa, México D.F., 14330, Méxicoes_ES
dc.contributor.emailslcruz@cinvestav.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeTarrytow NYes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.pbb.2012.03.018es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaToluene misuse usually initiates at an early age when the central nervous system is still immature, causing deleterious effects such as cognitive impairment. Epigenetic regulatory mechanisms have been proposed to explain long-term changes involved not only in memory, but also in toluene's actions. The aim of this study was to evaluate the effects of acute and chronic toluene exposure on learning, memory and histone acetylation in the rat hippocampus during two stages of life: adolescence and young adulthood. Because the memory tests used in this work involved object exploration and the perception of a noxious stimulus, general activity and nociception tests were also conducted. Acute and chronic toluene inhalation impaired learning, short-term and long-term memory in an object-recognition test and in an inhibitory avoidance task in both groups of age. This effect was concentration-dependent and occurred even at low toluene concentrations (1000, 2000 ppm) that were otherwise non-effective. Acute toluene inhalation produced antinociception, and tolerance to this effect developed after chronic exposure. Histone acetylation in the dentate gyrus showed differences depending on the histone, treatment and age: a single toluene exposure increased H4 acetylation in adolescents and young adult rats, whereas chronic exposure decreased H3 acetylation, but only in adults. In conclusion, this work provides evidence of toluene-induced impairment on learning, short- and long-term memory in adolescent and young adult rats, and shows that even a single toluene exposure can induce epigenetic modifications in the rat hippocampus.es_ES
dc.subject.kwToluenoes_ES
dc.subject.kwSolventeses_ES
dc.subject.kwMemoriaes_ES
dc.subject.kwAprendizajees_ES
dc.subject.kwNocicepciónes_ES
dc.subject.kwActividad locomotoraes_ES
dc.subject.kwToleranciaes_ES
dc.subject.kwMecanismos epigenéticoses_ES
dc.subject.koToluenees_ES
dc.subject.koSolventses_ES
dc.subject.koLearninges_ES
dc.subject.koMemoryes_ES
dc.subject.koNociceptiones_ES
dc.subject.koLocomotor activityes_ES
dc.subject.koTolerancees_ES
dc.subject.koEpigenetic mechanismses_ES


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