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Treatment discontinuation and clinical outcomes in the 1-year naturalistic treatment of patients with schizophrenia at risk of treatment nonadherence

dc.creatorKelin, Katarina
dc.creatorLambert, Timothy J.R.
dc.creatorBrnabic, Alan J.M.
dc.creatorNewton, Richard
dc.creatorYe, Wendy
dc.creatorEscamilla, Raúl I.
dc.creatorChen, Kuang-Peng
dc.creatorDon, Liana
dc.creatorMontgomery, William
dc.creatorKaragianis, Jamie
dc.creatorAscher-Svanum, Haya
dc.date.accessioned2017-06-29T06:08:42Z
dc.date.available2017-06-29T06:08:42Z
dc.date.issued2011es_ES
dc.identifier692es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5376
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105874/es_ES
dc.identifier.urihttps://doi.org/10.2147/PPA.S16800es_ES
dc.language.isoenges_ES
dc.relation5, 213-222 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleTreatment discontinuation and clinical outcomes in the 1-year naturalistic treatment of patients with schizophrenia at risk of treatment nonadherencees_ES
dc.typearticlees_ES
dc.contributor.affiliationEli Lilly Australia Pty Ltd, West Ryde, NS W, Australiaes_ES
dc.contributor.emailkelin_katarina@lilly.comes_ES
dc.relation.jnabreviadoPATIENT PREFER ADHERes_ES
dc.relation.journalPatient Preference and Adherencees_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.2147/PPA.S16800es_ES
dc.description.abstractotrodiomaBackground: This study aimed to improve physicians’ understanding of the treatment circumstances and needs of outpatients with schizophrenia at risk of nonadherence, by naturalistically assessing antipsychotic treatment patterns, clinical outcomes, and health care service use in this little-studied patient population. Methods: In this one-year, prospective, multicenter, noninterventional, observational study, patients considered at risk of nonadherence by their physicians were switched from their primary oral antipsychotic to another oral or a depot antipsychotic at study entry. All cause treatment discontinuation (antipsychotic switch, augmentation, or discontinuation) during the study was assessed using Kaplan–Meier survival analyses and descriptive statistics. Patients’ illness severity, quality of life, attitude towards medication, patient-reported adherence, and health care resource utilization were assessed during the study. Results: Of the 406 enrolled patients, 43 (10.6%) were switched to depot and 363 (89.4%) were switched to oral antipsychotics at study entry. During the study, 99 (24.4%) patients switched, augmented, or discontinued their antipsychotic (all cause treatment discontinuation). Of the 99 patients who switched, augmented, or discontinued their antipsychotic, 8 (18.6%) were taking depot and 91 (25.0%) were taking oral antipsychotics. These patients were switched to either depot (n = 15) or oral (n = 78) antipsychotics, or discontinued their antipsychotic medication (n = 6). Inadequate response was the most frequently reported reason for medication discontinuation. During the study, patients’ clinical and functional status improved significantly and service use was low. Most patients considered themselves to be adherent at study entry, and this favorable self-perception increased during the study (from 68.5% to 88.1%). Conclusion: Although identified as at risk of nonadherence, few patients in this naturalistic study discontinued their prescribed antipsychotic medication during the study. The discrepancy between the physicians’ perception of their patient’s medication adherence and the patients’ self-perceived adherence highlights the need to better understand the underlying reasons for this phenomenon.es_ES
dc.subject.kwDrogas antipsicóticases_ES
dc.subject.kwPersistencia en la medicaciónes_ES
dc.subject.kwPacientes ambulatorioses_ES
dc.subject.kwEsquizofreniaes_ES
dc.subject.kwDepósito antipsicóticoes_ES
dc.subject.kwIncumplimientoes_ES
dc.subject.koAntipsychotic drugses_ES
dc.subject.koMedication persistencees_ES
dc.subject.koOutpatientses_ES
dc.subject.koSchizophreniaes_ES
dc.subject.koDepot antipsychotices_ES
dc.subject.koNonadherencees_ES


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