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No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data

dc.creatorTovilla-Zarate, Carlos
dc.creatorJuarez-Rojop, Isela
dc.creatorRamon-Frias, Teresa
dc.creatorVillar-Soto, Mario
dc.creatorPool-Garcia, Sherezada
dc.creatorCamarena Medellin, Beatriz
dc.creatorGenis Mendoza, Alma D.
dc.creatorLopez Narvaez, Lilia
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-29T06:08:00Z
dc.date.available2017-06-29T06:08:00Z
dc.date.issued2011es_ES
dc.identifier681es_ES
dc.identifier.urihttp://www.biomedcentral.com/content/pdf/1471-244X-11-151.pdfes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5365
dc.identifier.urihttps://doi.org/10.1186/1471-244X-11-151es_ES
dc.language.isoenges_ES
dc.relation11, 151 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshCatechol-O-Methyltransferasees_ES
dc.subject.meshGene-Gene Interactiones_ES
dc.subject.meshFunctional Polymorphismes_ES
dc.subject.meshTreatment Responsees_ES
dc.subject.meshAnger Traitses_ES
dc.subject.meshSchizophreniaes_ES
dc.subject.meshDisorderses_ES
dc.subject.meshPersonalityes_ES
dc.subject.meshMetaboliteses_ES
dc.subject.meshGenotypees_ES
dc.titleNo association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new dataes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", México D. F., Méxicoes_ES
dc.contributor.emailalfonso_tovillaz@yahoo.com.mxes_ES
dc.relation.jnabreviadoBMC PSYCHIATRYes_ES
dc.relation.journalBioMed Central Psychiatryes_ES
dc.identifier.placeLondreses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1471-244Xes_ES
dc.identifier.doi10.1186/1471-244X-11-151es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaBackground: The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies-we carried out a meta-analysis. Methods: We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases. Results: No significant differences were found in the distribution of alleles (chi(2) = 0.33, 1 df, p = 0.56) or genotypes (chi(2) = 2.36, 2 df, p = 0.26). The meta-analysis comprising 12 association studies (including the present one) showed that the risk COMTmet allele of COMTval158/met is not associated with suicidal behavior (OR: 1.09, 95% CI: 0.97-1.23), even in the absence of heterogeneity (OR: 1.09, 95% CI: 0.97-1.23). Conclusion: Our results showed no association between COMTval158/met and suicidal behavior. However, more studies are necessary to determine conclusively an association between COMT and suicidal behaviores_ES
dc.subject.kwPsiquiatríaes_ES
dc.subject.koPsychiatryes_ES


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