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Antidepressant effects of estrogens: a basic approximation

dc.creatorEstrada-Camarena, Erika
dc.creatorLópez-Rubalcava, Carolina
dc.creatorVega-Rivera, Nelly
dc.creatorRécamier-Carballo, Soledad
dc.creatorFernández-Guasti, Alonso
dc.date.accessioned2017-06-29T06:05:55Z
dc.date.available2017-06-29T06:05:55Z
dc.date.issued2010es_ES
dc.identifier644es_ES
dc.identifier.issn1473-5849es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5328
dc.identifier.urihttp://doi.org/10.1097/FBP.0b013e32833db7e9es_ES
dc.language.isoenges_ES
dc.relation21 (5-6) 451-464 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAntidepressant effects of estrogens: a basic approximationes_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Méxicoes_ES
dc.contributor.emailjfernand@cinvestav.mxes_ES
dc.relation.jnabreviadoBEHAV PHARMACOLes_ES
dc.relation.journalBehavioural Pharmacologyes_ES
dc.identifier.placePhiladelphiaes_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn0955-8810es_ES
dc.identifier.doi10.1097/FBP.0b013e32833db7e9es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThe use of estrogenic compounds as antidepressants or as coadjuvants to facilitate the effect of antidepressants has reported controversial results, suggesting that many factors could influence their actions. This review analyzes, from a basic research perspective, the possible factors that may underlie the antidepressant action of estrogens alone or in combination. The possible mechanisms of action of estrogens alone and in combination with the selective serotonin reuptake inhibitor, fluoxetine, the selective noradrenaline reuptake inhibitor, desipramine, and the mixed serotonin/noradrenaline reuptake inhibitor, venlafaxine are reviewed, focusing on monoaminergic systems and estrogen receptors as main targets. The antidepressant effect of estrogens depends on the type of estrogen, treatment duration, doses, sex, time after ovariectomy, and age. Estrogens potentiate the antidepressant-like action of fluoxetine, venlafaxine, and desipramine and drastically shorten their latency of action. The antidepressant-like effect of estrogens alone or in combination with antidepressants seems to be mediated by monoaminergic and classic estrogen receptors, as WAY100635, an antagonist to the serotonin 1A receptor, idaxozan, an antagonist to a2 adrenergic receptors, and RU 58668, an estrogen receptor antagonist, blocked their antidepressant-like effect. In conclusion, estrogens produce antidepressant-like actions by themselves and importantly facilitate the action of clinically used antidepressantses_ES
dc.subject.kw17 A-ethyinyl-estradioles_ES
dc.subject.kw17 b-estradioles_ES
dc.subject.kwAntidepresivos-como acciónes_ES
dc.subject.kwExamen de nado forzadoes_ES
dc.subject.kwNoradrenalinaes_ES
dc.subject.kwSerotoninaes_ES
dc.subject.ko17 a-ethyinyl-estradioles_ES
dc.subject.ko17 b-estradioles_ES
dc.subject.koAntidepressant-like actiones_ES
dc.subject.koForced swimming testes_ES
dc.subject.koNoradrenalinees_ES
dc.subject.koSerotonines_ES


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