Mostrar el registro sencillo del ítem

Involvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexia

dc.creatorDe Gortari, Patricia
dc.creatorMancera, Karen
dc.creatorCote-Vélez, Antonieta
dc.creatorAmaya, María Isabel
dc.creatorMartínez, Adrián
dc.creatorJaimes-Hoy, Lorraine
dc.creatorJoseph-Bravo, Patricia
dc.date.accessioned2017-06-29T06:05:11Z
dc.date.available2017-06-29T06:05:11Z
dc.date.issued2009es_ES
dc.identifier628es_ES
dc.identifier.issn0306-4530es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5312
dc.identifier.urihttps://doi.org/10.1016/j.psyneuen.2008.09.010es_ES
dc.language.isoenges_ES
dc.relation34 (2) 259-272 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnorexia-Chemically inducedes_ES
dc.subject.meshAnorexia-Metabolismes_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshDehydration-Complicationses_ES
dc.subject.meshDown-Regulationes_ES
dc.subject.meshFeeding Behaviores_ES
dc.subject.meshFemalees_ES
dc.subject.meshMalees_ES
dc.subject.meshParaventricular Hypothalamic Nucleus-metabolismes_ES
dc.subject.meshPeptide Fragments-Pharmacologyes_ES
dc.subject.meshPituitary Gland-Physiologyes_ES
dc.subject.meshRNA, Messenger-Metabolismes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, Corticotropin-Releasing Hormone-Antagonists & inhibitors Receptorses_ES
dc.subject.meshSex Characteristicses_ES
dc.subject.meshThyroid Gland-Physiologyes_ES
dc.subject.meshThyrotropin-Releasing Hormone-Metabolismes_ES
dc.subject.meshCorticotropin-Releasing Hormone-Metabolismes_ES
dc.titleInvolvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexiaes_ES
dc.typearticlees_ES
dc.contributor.affiliationDivisión de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría RFM, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, 14370 México, D.F., Mexico.es_ES
dc.contributor.emailgortari@imp.edu.mxes_ES
dc.relation.jnabreviadoPSYCHONEUROENDOCRINOLOGYes_ES
dc.relation.journalPsychoneuroendocrinologyes_ES
dc.identifier.placeEnglandes_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-3360es_ES
dc.identifier.doi10.1016/j.psyneuen.2008.09.010es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaWistar rats subjected to dehydration-induced anorexia (DIA), with 2.5% NaCl solution as drinking water for 7 days, decrease by 80% their food intake and present some changes common to pair-fed food restricted rats (FFR) such as: weight loss, decreased serum leptin and expression of orexigenic arcuate peptides, increasing the anorexigenic ones and serum corticosterone levels. In contrast, the response of the HPT axis differs: DIA animals have increased TRH expression in PVN and present primary as opposed to the tertiary hypothyroidism of the FFR. Exclusive to DIA is the activation of CRHergic neurons in the lateral hypothalamus (LH) that project to PVN. Since TRH neurons of the PVN contain CRH receptors, we hypothesized that the differences in the response of the HPT axis to DIA could be due to CRH regulating TRHergic neurons. CRH effect was first evaluated on TRH expression of cultured hypothalamic cells where TRH mRNA levels increased after 1h with 0.1nM of CRH. We then measured the mRNA levels of CRH receptors in the PVN of male and female rats subjected to DIA; only those of CRH-R2 were modulated (down-regulated). The CRH-R2 antagonist antisauvagine-30 was therefore injected into the PVN of male rats, during the 7 days of DIA. Antisauvagine-30 induced a higher food intake than controls, and impeded the changes produced by DIA on the HPT axis: PVN TRH mRNA, and serum TH and TSH levels were decreased to similar values of FFR animals. Results corroborate the anorexigenic effect of CRH and show its role, acting through CRH-R2 receptors, in the activation of TRHergic PVN neurons caused by DIA. These new data further supports clinical trials with CRH-R2 antagonists in anorexia nervosa patients.es_ES
dc.subject.kwHormona liberadora de tirotropina (HLT)es_ES
dc.subject.kwEje de la tiroideses_ES
dc.subject.kwAnorexia nerviosaes_ES
dc.subject.kwAntisauvagine-30es_ES
dc.subject.kwPVNes_ES
dc.subject.koTRHes_ES
dc.subject.koThyroid axises_ES
dc.subject.koAnorexia nervosaes_ES
dc.subject.koAntisauvagine-30es_ES
dc.subject.koPVNes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem