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Inhibitory effect of state independent ponto-geniculo-occipital waves on seizure occurrence induced by local application of penicillin into the temporal lobe amygdala

dc.creatorRamírez Salado, Ignacio
dc.creatorRivera García, Ana Paula
dc.creatorCruz Aguilar, Manuel Alejandro
dc.creatorCalvo, José María
dc.date.accessioned2017-06-29T06:03:22Z
dc.date.available2017-06-29T06:03:22Z
dc.date.issued2008es_ES
dc.identifier581es_ES
dc.identifier.issn0278-5846es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5266
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2008.07.004es_ES
dc.language.isoenges_ES
dc.relation32 (7) 1688-1697 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAmygdala-Drug effectses_ES
dc.subject.meshAmygdala-Physiologyes_ES
dc.subject.meshAnalgesics, non-narcotic-Pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBrain mappinges_ES
dc.subject.meshCarbachol-Pharmacologyes_ES
dc.subject.meshCatses_ES
dc.subject.meshDisease models, animales_ES
dc.subject.meshElectroencephalography-Methodses_ES
dc.subject.meshGeniculate bodies-Physiopathologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMicroinjectionses_ES
dc.subject.meshNeural Pathways-Drug effectses_ES
dc.subject.meshNeural Pathways-Physiologyes_ES
dc.subject.meshOccipital Lobe-Physiopathologyes_ES
dc.subject.meshPenicillin Ges_ES
dc.subject.meshPons-Physiopathologyes_ES
dc.subject.meshReaction time-Drug effectses_ES
dc.subject.meshReaction Time-Physiologyes_ES
dc.subject.meshSeizures-Chemically inducedes_ES
dc.subject.meshSeizures-Pathologyes_ES
dc.subject.meshSeizures-Physiopathologyes_ES
dc.subject.meshSleep-Drug effectses_ES
dc.subject.meshSleep-Pysiologyes_ES
dc.subject.meshTemporal lobe-Drug effectses_ES
dc.subject.meshTemporal lobe-Physiologyes_ES
dc.subject.meshWakefulness-Drug effectses_ES
dc.subject.meshWakefulness-Physiologyes_ES
dc.titleInhibitory effect of state independent ponto-geniculo-occipital waves on seizure occurrence induced by local application of penicillin into the temporal lobe amygdalaes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Cronobiología, División de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370, México, D.F. Mexicoes_ES
dc.contributor.emailsalado@imp.edu.mxes_ES
dc.relation.jnabreviadoPROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRYes_ES
dc.relation.journalProgress in Neuro-psychopharmacology and Biological Psychiatryes_ES
dc.identifier.placeEnglandes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1878-4216es_ES
dc.identifier.doi10.1016/j.pnpbp.2008.07.004es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaPURPOSE: In order to explore the possible inhibitory role of the phasic phenomena of REM sleep ponto-geniculo-occipital (PGO) waves over epilepsy, seizure activity produced by topic administration of Na-penicillin (PCN) has been analyzed during sustained PGO waves irrespective of current state. PGO waves were induced by the injection of carbachol in the peribrachial area. METHODS: The development of acute experimental epilepsy was compared among nine chronically implanted, adult, male cats, by means of polygraphic 23 h recordings. Our protocol consisted of sets of 4 trials: carbachol; PCN; carbachol followed by PCN and finally PCN followed by carbachol. Each cat received one single set and all trials were carried out with a seven days interval, in order to compare the epileptic activity both in the presence of PGOs and without them. RESULTS: PGO waves 1) exert an inhibitory influence over number and duration of the Generalized Convulsive Seizures (GCSs) and 2) spike frequency; 3) increase the latency of GCSs; and 4) restores sleep alterations produced by experimental epilepsy. CONCLUSIONS: PGO waves exhibit an inhibitory influence over seizures induced by PCN. These data support the hypothesis that this phasic phenomenon of REM sleep have a depressant effect on epilepsy, inhibit seizures and normalize sleep architecture changes induced by seizures. We suggest that one possible function of PGO activity is to protect the brain from intense changes in neuronal excitability; namely convulsive activity.es_ES
dc.subject.koAmygdalaes_ES
dc.subject.koCarbacholes_ES
dc.subject.koEpilepsyes_ES
dc.subject.koPeribrachial area (PBL)es_ES
dc.subject.koPonto-geniculo-occipital waves (PGO)es_ES
dc.subject.koSleepes_ES


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