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Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats

dc.creatorMartínez-Mota, Lucía
dc.creatorCruz-Martínez, Juan José
dc.creatorMárquez-Baltazar, Sergio
dc.creatorFernández-Guasti, Alonso
dc.date.accessioned2017-06-29T06:03:17Z
dc.date.available2017-06-29T06:03:17Z
dc.date.issued2008es_ES
dc.identifier578es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5264
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2007.09.003es_ES
dc.language.isoenges_ES
dc.relation88 (3) 332-340 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAndrostenedione-analogs & derivativeses_ES
dc.subject.meshAndrostenedione-pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive Agents, Second-Generation-pharmacologyes_ES
dc.subject.meshAntidepressive Agents, Tricyclic-pharmacologyes_ES
dc.subject.meshAromatase Inhibitors-pharmacologyes_ES
dc.subject.meshBrain Chemistry-drug effectses_ES
dc.subject.meshDesipramine-pharmacologyes_ES
dc.subject.meshEstradiol-bloodes_ES
dc.subject.meshEstradiol-pharmacologyes_ES
dc.subject.meshEstrogens-physiologyes_ES
dc.subject.meshFemalees_ES
dc.subject.meshFluoxetine-pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMotor Activity-drug effectses_ES
dc.subject.meshOrchiectomyes_ES
dc.subject.meshOvariectomyes_ES
dc.subject.meshRats 4Swimming-psychologyes_ES
dc.subject.meshTestosterone-bloodes_ES
dc.titleEstrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. Mexico-Xochimilco 101, Tlalpan, Mexico City 14370, Mexico.es_ES
dc.contributor.emaillucia@imp.edu.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeUnited Stateses_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2007.09.003es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaIn male rats, the antidepressant-like effect of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST) is reduced by orchidectomy and partially restored by testosterone (T). It is unknown if this modulation of T is produced by its estrogenic metabolites. The objectives of this study were to evaluate if the aromatase inhibitor, formestane, interferes with the antidepressant-like effect of DMI and FLX in intact male rats, and to analyze if 17beta-estradiol (E2) modifies the FST and interacts with the antidepressants in orchidectomized (Orx) males. Intact males received DMI (1.25-5.0 mg-kg) and FLX (2.5-10 mg-kg) alone or in combination with formestane (17.5 mg-kg). Orx rats received E2 (5, 10, 20 and 40 microg-rat) or the combination of E2 [at sub-threshold (5 microg-rat) and optimal (10 microg-rat) doses] plus sub-effective doses of DMI (2.5 mg-kg) or FLX (10 mg-kg). Serum testosterone and estradiol levels were measured in intact-control and -formestane treated animals as well as in castrated males replaced with various doses of E2. Formestane in intact males lacked of an action in the FST, but cancelled the antidepressant-like effect of DMI and FLX. E2 at the supra-physiological doses of 10 and 20 microg-rat produced antidepressant-like effects. E2 at 5 microg-rat (that re-established the levels of this hormone to physiological levels) and at 10 microg-rat restored the antidepressant-like action of DMI and FLX in Orx rats. It was concluded that estrogens participate in the antidepressant-like effect of DMI and FLX in the FST.es_ES
dc.subject.koAromatase inhibitiones_ES
dc.subject.koEstrogens; 17_-Estradioles_ES
dc.subject.koDesipraminees_ES
dc.subject.koFluoxetinees_ES
dc.subject.koForced swimming testes_ES
dc.subject.koAntidepressantses_ES
dc.subject.koMale ratses_ES


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