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Acute ethanol induces Fos in GABAergic and non-GABAergic forebrain neurons: a double-labeling study in the medial prefrontal cortex and extended amygdala

dc.creatorLeriche, M.
dc.creatorMéndez, M.
dc.creatorZimmer, L.
dc.date.accessioned2017-06-29T06:03:14Z
dc.date.available2017-06-29T06:03:14Z
dc.date.issued2008es_ES
dc.identifier575es_ES
dc.identifier.issn0306-4522es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5262
dc.identifier.urihttps://doi.org/10.1016/j.neuroscience.2008.01.069es_ES
dc.language.isoenges_ES
dc.relation153 (1) 259-267 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAlcohol-Induced Disorderses_ES
dc.subject.meshNervous System-Physiopathologyes_ES
dc.subject.meshAmygdala-Anatomy & histologyes_ES
dc.subject.meshAmygdala-Drug effectses_ES
dc.subject.meshAmygdala-Metabolismes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBiological Markers-Analysises_ES
dc.subject.meshBiological Markers-Metabolismes_ES
dc.subject.meshCell Countes_ES
dc.subject.meshCentral Nervous System Depressants-Pharmacologyes_ES
dc.subject.meshDrug Administration Schedulees_ES
dc.subject.meshEthanol-Pharmacologyes_ES
dc.subject.meshGlutamate Decarboxylase-Drug effectses_ES
dc.subject.meshGlutamate Decarboxylase-Metabolismes_ES
dc.subject.meshImmunohistochemistryes_ES
dc.subject.meshMalees_ES
dc.subject.meshNeurons-Drug effectses_ES
dc.subject.meshNeurons-Metabolismes_ES
dc.subject.meshNucleus Accumbens-Drug effectses_ES
dc.subject.meshNucleus Accumbens-Metabolismes_ES
dc.subject.meshPrefrontal Cortex-Anatomy & histologyes_ES
dc.subject.meshPrefrontal Cortex-Drug effectses_ES
dc.subject.meshPrefrontal Cortex-Metabolismes_ES
dc.subject.meshProto-Oncogene Proteins c-fos-Drug effectses_ES
dc.subject.meshProto-Oncogene Proteins c-fos-Metabolismes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Sprague-Dawleyes_ES
dc.subject.meshStaining and Labelinges_ES
dc.subject.meshUp-Regulation-Drug effectses_ES
dc.subject.meshUp-Regulation-Physiologyes_ES
dc.subject.meshGamma-Aminobutyric Acid-Metabolismes_ES
dc.titleAcute ethanol induces Fos in GABAergic and non-GABAergic forebrain neurons: a double-labeling study in the medial prefrontal cortex and extended amygdalaes_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, 14370 México DF, Mexico.es_ES
dc.relation.jnabreviadoNEUROSCIENCEes_ES
dc.relation.journalNeurosciencees_ES
dc.identifier.placeOxford, Elmsford, N. Y., Pergamon Presses_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7544es_ES
dc.identifier.doi10.1016/j.neuroscience.2008.01.069es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaThe purpose of this study was to further address the hypothesis that ethanol activates GABAergic neurons in specific brain neurocircuits that mediate motivated behavior and control of action, such as the central extended amygdala and medial prefrontal cortex. Male Sprague-Dawley rats received habituation to 7 days of daily intragastric administration of water (5 ml-kg) followed by a single acute intragastric dose of ethanol (2.5 g-kg) or water then, 2 h later, by paraformaldehyde perfusion. Rats left undisturbed in the animal room throughout the experiment were also perfused (naive group). Brain sections were processed for single Fos immunohistochemistry or dual Fos immunohistochemistry-glutamic acid decarboxylase (GAD) mRNA in situ hybridization. Intragastric water administration increased the number of Fos-immunoreactive cells in the infralimbic cortex and lateral part of the central nucleus of the amygdala compared with the naive group. Ethanol administration increased the number of Fos-immunoreactive cells in the infralimbic (+57.5%) and prelimbic (+105.3%) cortices, nucleus accumbens shell region (+88.2%), medial part of the central nucleus of the amygdala (+160%), and lateral part of the bed nucleus of the stria terminalis (+198.8%) compared with the water-treated group. In the nucleus accumbens shell region, central nucleus of the amygdala, and bed nucleus of the stria terminalis, more than 80% of Fos-immunoreactive neurons were GABAergic after ethanol administration. In contrast, in the prelimbic cortex, 75% of Fos-immunoreactive neurons were not GABAergic. These results constitute new evidence for region-specific functional interactions between ethanol and GABAergic neurons.es_ES
dc.subject.kwAlcoholes_ES
dc.subject.kwDescarboxilasa del ácido glutámicoes_ES
dc.subject.kwHibridación in situes_ES
dc.subject.kwNúcleo accumbenses_ES
dc.subject.kwCama núcleo de la estría terminales_ES
dc.subject.kwNúcleo central de la amígdalaes_ES
dc.subject.koGlutamic acid decarboxylasees_ES
dc.subject.koAlcoholes_ES
dc.subject.koIn situ hybridizationes_ES
dc.subject.koNucleus accumbenses_ES
dc.subject.koBed nucleus of the stria terminalises_ES
dc.subject.koCentral nucleus of the amygdalaes_ES


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