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Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain

dc.creatorMorissette, M.
dc.creatorLe Saux, M.
dc.creatorD'Astous, M.
dc.creatorJourdain, S.
dc.creatorAl Sweidi, S.
dc.creatorMorin, N.
dc.creatorEstrada-Camarena, E.
dc.creatorMéndez, P.
dc.creatorGarcía-Segura, L.M.
dc.creatorDi Paolo, T.
dc.date.accessioned2017-06-29T06:03:08Z
dc.date.available2017-06-29T06:03:08Z
dc.date.issued2008es_ES
dc.identifier572es_ES
dc.identifier.issn0960-0760es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5259
dc.identifier.urihttps://doi.org/10.1016/j.jsbmb.2007.09.011es_ES
dc.language.isoenges_ES
dc.relation108 (3-5) 327-338 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBrain-drug effectses_ES
dc.subject.meshDopamine-physiologyes_ES
dc.subject.meshEstradiol-pharmacologyes_ES
dc.subject.meshEstrogen Receptor alpha-agonistses_ES
dc.subject.meshEstrogen Receptor alpha-physiologyes_ES
dc.subject.meshEstrogen Receptor beta-agonistses_ES
dc.subject.meshEstrogen Receptor beta-physiologyes_ES
dc.subject.meshFemalees_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshNeurons-drug effectses_ES
dc.subject.meshNeuroprotective Agents-pharmacologyes_ES
dc.subject.meshNitriles-pharmacologyes_ES
dc.subject.meshPhenols-pharmacologyes_ES
dc.subject.meshPyrazoles-pharmacologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshReceptors, Dopamine D2-metabolismes_ES
dc.titleContribution of estrogen receptors alpha and beta to the effects of estradiol in the braines_ES
dc.typearticlees_ES
dc.contributor.affiliationMolecular Endocrinology and Oncology Research Center, Medical Center and Faculty of Pharmacy, Laval University, 2705 Laurier Boulevard, Sainte-Foy, Québec, Canada.es_ES
dc.contributor.emailtherese.dipaolo@crchul.ulaval.caes_ES
dc.relation.jnabreviadoJ STEROID BIOCHEM MOL BIOLes_ES
dc.relation.journalJournal of Steroid Biochemistry and Molecular Biologyes_ES
dc.identifier.placeEnglandes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1879-1220es_ES
dc.identifier.doi10.1016/j.jsbmb.2007.09.011es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaClinical and experimental studies show a modulatory role of estrogens in the brain and suggest their beneficial action in mental and neurodegenerative diseases. The estrogen receptors ERalpha and ERbeta are present in the brain and their targeting could bring selectivity and reduced risk of cancer. Implication of ERs in the effect of estradiol on dopamine, opiate and glutamate neurotransmission is reviewed. The ERalpha agonist, PPT, is shown as estradiol to modulate hippocampal NMDA receptors and AMPA receptors in cortex and striatum of ovariectomized rats whereas the ERbeta agonist DPN is inactive. Striatal DPN activity suggests implication of ERbeta in estradiol modulation of D2 receptors and transporters in ovariectomized rats and is supported by the lack of effect of estradiol in ERbeta knockout (ERKObeta) mice. Both ERalpha and ERbeta agonists modulate striatal preproenkephalin (PPE) gene expression in ovariectomized rats. In male mice PPT protects against MPTP toxicity to striatal dopamine; this implicates Akt-GSK3beta signaling and the apoptotic regulators Bcl2 and Bad. This suggests a role for ERalpha in striatal dopamine neuroprotection. ERKOalpha mice are more susceptible to MPTP toxicity and not protected by estradiol; differences in ERKObeta mice are subtler. These results suggest therapeutic potential for the brain of ER specific agonists.es_ES
dc.subject.kwEstradioles_ES
dc.subject.kwDopaminaes_ES
dc.subject.kwPPTes_ES
dc.subject.kwDPNes_ES
dc.subject.kwReceptor NMDAes_ES
dc.subject.kwReceptor AMPAes_ES
dc.subject.kwVía PI3Kes_ES
dc.subject.koEstradioles_ES
dc.subject.koDopaminees_ES
dc.subject.koPPTes_ES
dc.subject.koDPNes_ES
dc.subject.koNMDA receptores_ES
dc.subject.koAMPA receptores_ES
dc.subject.koPI3K pathwayes_ES


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