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Coincidence detection of convergent perforant path and mossy fibre inputs by CA3 interneurons

dc.creatorCalixto, Eduardo
dc.creatorGalván, Emilio J.
dc.creatorCard, J. Patrick
dc.creatorBarrionuevo, Germán
dc.date.accessioned2017-06-29T06:03:06Z
dc.date.available2017-06-29T06:03:06Z
dc.date.issued2008es_ES
dc.identifier571es_ES
dc.identifier.issn0022-3751es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5258
dc.identifier.urihttps://doi.org/10.1113/jphysiol.2008.152751es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536585/es_ES
dc.language.isoenges_ES
dc.relation586 (ptp.11) 2695-2712 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAction potentials-Physiologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshEvoked potentials-Physiologyes_ES
dc.subject.meshHippocampus-Physiologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMossy fibers, hippocampal-Physiologyes_ES
dc.subject.meshPerforant pathway-Physiologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Sprague-Dawleyes_ES
dc.titleCoincidence detection of convergent perforant path and mossy fibre inputs by CA3 interneuronses_ES
dc.typearticlees_ES
dc.contributor.affiliationDivisión de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente, México City, México.es_ES
dc.contributor.emailgerman@bs.pitt.edues_ES
dc.relation.jnabreviadoJ PHYSIOLes_ES
dc.relation.journalJournal of Physiologyes_ES
dc.identifier.placeEnglandes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1469-7793es_ES
dc.identifier.doi10.1113/jphysiol.2008.152751es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaWe performed whole-cell recordings from CA3 s. radiatum (R) and s. lacunosum-moleculare (L-M) interneurons in hippocampal slices to examine the temporal aspects of summation of converging perforant path (PP) and mossy fibre (MF) inputs. PP EPSPs were evoked from the s. lacunosum-moleculare in area CA1. MF EPSPs were evoked from the medial extent of the suprapyramidal blade of the dentate gyrus. Summation was strongly supralinear when examining PP EPSP with MF EPSP in a heterosynaptic pair at the 10 ms ISI, and linear to sublinear at longer ISIs. This pattern of nonlinearities suggests that R and L-M interneurons act as coincidence detectors for input from PP and MF. Summation at all ISIs was linear in voltage clamp mode demonstrating that nonlinearities were generated by postsynaptic voltage-dependent conductances. Supralinearity was not detected when the first EPSP in the pair was replaced by a simulated EPSP injected into the soma, suggesting that the conductances underlying the EPSP boosting were located in distal dendrites. Supralinearity was selectively eliminated with either Ni2+ (30 microm), mibefradil (10 microm) or nimodipine (15 microm), but was unaffected by QX-314. This pharmacological profile indicates that supralinearity is due to recruitment of dendritic T-type Ca2+channels by the first subthreshold EPSP in the pair. Results with the hyperpolarization-activated (Ih) channel blocker ZD 7288 (50 microm) revealed that Ih restricted the time course of supralinearity for coincidently summed EPSPs, and promoted linear to sublinear summation for asynchronous EPSPs. We conclude that coincidence detection results from the counterbalanced activation of T-type Ca2+ channels and inactivation of Ih.es_ES


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