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Ethanol-induced changes in proenkephalin mRNA expression in the rat nigrostriatal pathway

dc.creatorMéndez, Milagros
dc.creatorMorales-Mulia, Marcela
dc.creatorPérez-Luna, José Manuel
dc.date.accessioned2017-06-29T06:03:05Z
dc.date.available2017-06-29T06:03:05Z
dc.date.issued2008es_ES
dc.identifier570es_ES
dc.identifier.issn0895-8696es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5257
dc.identifier.urihttps://doi.org/10.1007/s12031-008-9039-9es_ES
dc.language.isoenges_ES
dc.relation34 (3) 225-234 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAlcohol-Induced Disorderses_ES
dc.subject.meshNervous System-Metabolismes_ES
dc.subject.meshNervous System-Physiopathologyes_ES
dc.subject.meshAlcoholism-Geneticses_ES
dc.subject.meshAlcoholism-Metabolismes_ES
dc.subject.meshAlcoholism-Physiopathologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCentral Nervous System Depressants-Pharmacologyes_ES
dc.subject.meshCorpus Striatum-Drug effectses_ES
dc.subject.meshCorpus Striatum-Metabolismes_ES
dc.subject.meshDopamine-Metabolismes_ES
dc.subject.meshEnkephalins-Geneticses_ES
dc.subject.meshEthanol-Pharmacologyes_ES
dc.subject.meshGene Expression Regulation-Drug effectses_ES
dc.subject.meshMalees_ES
dc.subject.meshNeural Pathways-Drug effectses_ES
dc.subject.meshNeural Pathways-Metabolismes_ES
dc.subject.meshProtein Precursors-Geneticses_ES
dc.subject.meshRNA, Messenger-Metabolismes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshSubstance Related Disorders-Geneticses_ES
dc.subject.meshSubstance Related Disorders-Metabolismes_ES
dc.subject.meshSubstance Related isorders-Physiopathologyes_ES
dc.subject.meshSubstantia Nigra-Drug effectses_ES
dc.subject.meshSubstantia Nigra-Metabolismes_ES
dc.subject.meshTime Factorses_ES
dc.subject.meshUp-Regulation-Drug effectses_ES
dc.subject.meshUp-Regulation-Geneticses_ES
dc.titleEthanol-induced changes in proenkephalin mRNA expression in the rat nigrostriatal pathwayes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Neuroquímica, Calzada México Xochimilco 101, Col. San Lorenzo Huipulco, 14370, México D.F., México.es_ES
dc.contributor.emailubach@imp.edu.mxes_ES
dc.relation.jnabreviadoJ MOL NEUROSCIes_ES
dc.relation.journalJournal of Molecular Neurosciencees_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1559-1166es_ES
dc.identifier.doi10.1007/s12031-008-9039-9es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaEndogenous opioid systems have been suggested to play a key role in ethanol reinforcement mechanisms and alcohol-drinking behavior. Ethanol induces differential alterations in opioid peptide expression in brain areas of the reward circuits, which may be linked to the reinforcing effects of ethanol. In addition, ethanol-induced alterations in opioidergic nigrostriatal transmission could be involved in brain sensitivity to ethanol and play a role in addictive processes. The aim of this work was to study the effects of acute ethanol administration on proenkephalin (proenk) mRNA expression in the rat substantia nigra and caudate-putamen (CP) for up to 24 h post treatment. Male Wistar rats received ethanol (2.5 g-kg) or distilled water by intragastric administration, and proenk mRNA expression was studied by in situ hybridization and densitometry. Ethanol transiently increased proenk mRNA expression in the CP 1 h after drug administration. Proenk mRNA levels remained elevated 2 h post treatment in the anterior-medial and medial-posterior regions of the CP. In contrast, ethanol decreased proenk mRNA expression in the substantia nigra pars compacta and pars reticulata 2 h after drug exposure. Alterations in enkephalin expression in the substantia nigra and CP in response to ethanol exposure could be involved in the mechanisms underlying brain sensitivity to the drug.es_ES
dc.subject.kwEtanoles_ES
dc.subject.kwPéptidos opioideses_ES
dc.subject.kwEncefalinases_ES
dc.subject.kwProencefalina mRNAes_ES
dc.subject.kwVía nigroestriatales_ES
dc.subject.koEthanoles_ES
dc.subject.koOpioid peptideses_ES
dc.subject.koEnkephalinses_ES
dc.subject.koProenkephalin mRNAes_ES
dc.subject.koNigrostriatal pathwayes_ES


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