Mostrar el registro sencillo del ítem

Sedative and anxiolytic efficacy of Tilia americana var. mexicana inflorescences used traditionally by communities of State of Michoacan, Mexico

dc.creatorPérez-Ortega, G.
dc.creatorGuevara-Fefer, P.
dc.creatorChávez, M.
dc.creatorHerrera, J.
dc.creatorMartínez, A.
dc.creatorMartínez, A.L.
dc.creatorGonzález-Trujano, M.E.
dc.date.accessioned2017-06-29T06:03:03Z
dc.date.available2017-06-29T06:03:03Z
dc.date.issued2008es_ES
dc.identifier569es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5256
dc.identifier.urihttps://doi.org/10.1016/j.jep.2007.12.007es_ES
dc.language.isoenges_ES
dc.relation116 (3) 461-468 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Anxiety Agents-adverse effectses_ES
dc.subject.meshAnti-Anxiety Agents-pharmacologyes_ES
dc.subject.meshBehavior, Animal-drug effectses_ES
dc.subject.meshDiazepam-pharmacologyes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshFlavonoids-analysises_ES
dc.subject.meshHypnotics and Sedatives-adverse effectses_ES
dc.subject.meshHypnotics and Sedatives-pharmacologyes_ES
dc.subject.meshImmobility Response, Tonic-drug effectses_ES
dc.subject.meshMalees_ES
dc.subject.meshMedicine, Traditionales_ES
dc.subject.meshMexicoes_ES
dc.subject.meshMicees_ES
dc.subject.meshMotor Activity-drug effectses_ES
dc.subject.meshPentobarbital-pharmacologyes_ES
dc.subject.meshPlant Extracts-chemistryes_ES
dc.subject.meshPlant Extracts-pharmacologyes_ES
dc.subject.meshTilia-chemistryes_ES
dc.titleSedative and anxiolytic efficacy of Tilia americana var. mexicana inflorescences used traditionally by communities of State of Michoacan, Mexicoes_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz., Sn Lorenzo Huipulco, 14370 México, D.F., Mexico.es_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.identifier.placeIrelandes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2007.12.007es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaAIM OF THE STUDY: Increasing demand of herbal products acquired in stores and markets, as well as medicinal plants collected for personal consume are a known modern tendency. In this study, the ethnomedicinal use of Tilia americana var. mexicana inflorescences as sedative and anxiolytic is reinforced by examinating inflorescences used by communities of the State of Michoacan, Mexico. MATERIALS AND METHODS: Experimental mouse models were used to evaluate the sodium pentobarbital (SP)-induced hypnosis potentiation, ambulatory activity, as well as sedative and anti-anxiety responses via oral administration of the aqueous extracts (10, 30 and-or 100 and 300mg-kg). RESULTS: All samples tested produced a lengthening in the time of SP. Moreover, a significant attenuation in the anxiety-response in the plus-maze test and a diminution in both the head dipping response and ambulatory activity were observed resembling the response to diazepam (0.3mg-kg, i.p.). TLC profiles of the samples showed similar pattern of flavonoids; HPLC-DAD exhibited peaks identified as derived of quercetin and kaempferol that may be responsible for the plant activity. CONCLUSIONS: Our results demonstrate that inflorescences of stored specimens obtained from popular local markets show the same effectiveness with regard to sedative and anxiolytic-like actions than freshly collected samples. Since no toxicity was observed through this route of administration (up to 5000mg-kg); therefore, it suggests that this plant is secure when used as tranquilizer in folk medicine.es_ES
dc.subject.koAnxiolytices_ES
dc.subject.koCentral nervous systemes_ES
dc.subject.koSedative-hypnotices_ES
dc.subject.koTilia americana vares_ES
dc.subject.koMexicanaes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem