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Cerebral blood flow changes associated with experimental pain stimulation in patients with major depression.

dc.creatorGraff-Guerrero, Ariel
dc.creatorPellicer, Francisco
dc.creatorMendoza-Espinosa, Yazmín
dc.creatorMartínez-Medina, Patricia
dc.creatorRomero-Romo, Juan
dc.creatorDe la Fuente-Sandoval, Camilo
dc.date.accessioned2017-06-29T06:02:58Z
dc.date.available2017-06-29T06:02:58Z
dc.date.issued2008es_ES
dc.identifier566es_ES
dc.identifier.issn0165-0327es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5253
dc.language.isoenges_ES
dc.relation107 (1-3) 161-168 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdultes_ES
dc.subject.meshAmbulatory Carees_ES
dc.subject.meshAntidepressive Agents-pharmacologyes_ES
dc.subject.meshAntidepressive Agents-therapeutic usees_ES
dc.subject.meshBrain-blood supplyes_ES
dc.subject.meshBrain-physiopathologyes_ES
dc.subject.meshBrain-radionuclide imaginges_ES
dc.subject.meshBrain Mappinges_ES
dc.subject.meshCerebral Cortex-physiopathologyes_ES
dc.subject.meshCerebral Cortex-radionuclide imaginges_ES
dc.subject.meshCysteine-analogs & derivativeses_ES
dc.subject.meshCysteine-diagnostic usees_ES
dc.subject.meshDepressive Disorder, Major-drug therapyes_ES
dc.subject.meshDepressive Disorder, Major-physiopathologyes_ES
dc.subject.meshDepressive Disorder, Major-radionuclide imaginges_ES
dc.subject.meshDiagnostic and Statistical Manual of Mental Disorderses_ES
dc.subject.meshFemalees_ES
dc.subject.meshFunctional Laterality-physiologyes_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshOrganotechnetium Compounds-diagnostic usees_ES
dc.subject.meshPain-physiopathologyes_ES
dc.subject.meshPain-psychologyes_ES
dc.subject.meshPain Threshold-physiologyes_ES
dc.subject.meshPain Threshold-psychologyes_ES
dc.subject.meshPhysical Stimulationes_ES
dc.subject.meshPressurees_ES
dc.subject.meshPsychiatric Status Rating Scaleses_ES
dc.subject.meshRegional Blood Flow-physiologyes_ES
dc.subject.meshTomography, Emission-Computed, Single-Photon-statistics & numerical dataes_ES
dc.titleCerebral blood flow changes associated with experimental pain stimulation in patients with major depression.es_ES
dc.typearticlees_ES
dc.contributor.affiliationCentre for Addiction and Mental Health, PET Centre, Toronto, Canada.es_ES
dc.relation.jnabreviadoJ AFFECT DISORDes_ES
dc.relation.journalJournal of Affective Disorderses_ES
dc.identifier.placeNetherlandses_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1573-2517es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaBACKGROUND: The clinical relationship between pain and depression has been extensively reported. The purpose of this study was to compare the cerebral blood flow (CBF) of patients with major depressive disorder (MDD) during stimulation with experimental pain tolerance or sham stimulation, before and after 2 weeks of at least partially effective antidepressant treatment (ADT), in order to determine the cerebral regions associated with pain processing in the two clinical states. METHODS: Twenty-four antidepressant-free outpatients diagnosed with MDD (DSM-IV), without any pain complaints and a basal score>or=20 points on the Hamilton Rating Scale for Depression were included. Cerebral SPECTs were performed before and after ADT. Patients were stimulated with pain pressure tolerance (PT) or sham stimulation during the radiotracer cerebral uptake time. RESULTS: The comparison between PT and sham stimulation before ADT showed an increase of CBF of PT stimulated patients in right temporal gyrus, left amygdale, right anterior cingulated cortex, bilateral medial frontal gyrus, bilateral insula, lingual gyrus, right precentral gyrus and left postcentral gyrus. Equal comparison after ADT showed an increase of CBF of PT stimulated patients only in left middle frontal gyrus. LIMITATIONS: The sample includes exclusively outpatients with mild-moderate depression. CONCLUSION: CBF before ADT increases in brain areas related with the affective and cognitive components of pain; in contrast, after ADT increases only in cognitive pain related areas. These results offer new avenues to investigate the cerebral substrate of the common relationship between pain and depression.es_ES
dc.subject.koPain tolerancees_ES
dc.subject.koDepressiones_ES
dc.subject.koNeuroimaginges_ES
dc.subject.koSPECTes_ES
dc.subject.koFrontal cortexes_ES
dc.subject.koAnterior cingulate cortexes_ES
dc.subject.koLimbices_ES
dc.subject.koSPM2es_ES
dc.subject.ko99m-Tc-ECDes_ES


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