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Role of nociceptin/orphanin FQ and the pseudopeptide [Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2 and their interaction with classic opioids in the modulation of thermonociception in the land snail Helix aspersa

dc.creatorMiller-Pérez, Carolina
dc.creatorSánchez-Islas, Eduardo
dc.creatorPellicer, Francisco
dc.creatorRodríguez-Manzo, Gabriela
dc.creatorCruz, Silvia L.
dc.creatorLeón-Olea, Martha
dc.date.accessioned2017-06-29T06:02:48Z
dc.date.available2017-06-29T06:02:48Z
dc.date.issued2008
dc.identifier560es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5247
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2007.11.039es_ES
dc.language.isoenges_ES
dc.relation581 (1-2) 77-85 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleRole of nociceptin/orphanin FQ and the pseudopeptide [Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2 and their interaction with classic opioids in the modulation of thermonociception in the land snail Helix aspersaes_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Histología y Microscopía Electrónica, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan. México D.F., C.P. 14370, Méxicoes_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean Journal of Pharmacologyes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1879-0712es_ES
dc.identifier.doi8080/10.1016/j.ejphar.2007.11.039es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaThe role in nociception of nociceptin-orphanin FQ (N-OFQ) and its receptor, the opioid receptor-like 1 (NOP), remains unclear because this peptide has been implicated in both suppression and enhancement of nociception. The present work characterises the effects of N-OFQ and the NOP receptor antagonist, the pseudopeptide [Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2 (Phe1_), on thermonociception in the snail Helix aspersa using the hot plate assay. Additionally, the possible interaction of each of these compounds with morphine or dynorphin A1–17 and naloxone was studied. Compounds were administered into the hemocoel cavity of H. aspersa and the latency to the aversive withdrawal behaviour recorded. Dose–response and time course curves were done. N-OFQ and naloxone produced a similar dose-dependent pronociceptive effect; however, N-OFQ reached its peak effect earlier and was 30 times more potent than naloxone. [Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2 and the opioid agonists, morphine and dynorphin A1–17produced antinociception with a similar efficacy, but [Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2 reached its peak effect more rapidly and lasted longer than that of dynorphin A1–17 and morphine. [Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2 was 50 times less potent than dynorphin A1–17, but 30 times more potent than morphine. N-OFQ significantly reduced morphine and dynorphin A1–17-induced antinociception. Combined administration of low doses of [Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2 and morphine or dynorphin A1–17produced a potent antinociceptive effect. Sub-effective doses of naloxone and N-OFQ also synergised to produce pronociception. Data suggest that these two opioid classes regulate nociception through parallel systems. The H. aspersa model appears as a valuable experimental preparation to continue the study of these opioid receptor systems.es_ES
dc.subject.koNociceptin-orphanin FQes_ES
dc.subject.ko[Phe1_(CH2NH)Gly2]-nociceptin(1–13)-NH2es_ES
dc.subject.koOpioid peptidees_ES
dc.subject.koThermonociceptiones_ES
dc.subject.koLand snailes_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koInvertebrateses_ES


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