Mostrar el registro sencillo del ítem

Dopamine receptors in the anterior insular cortex modulate long-term nociception in the rat

dc.creatorCoffeen, Ulises
dc.creatorLópez-Ávila, Alberto
dc.creatorOrtega-Legaspi, J. Manuel
dc.creatorDel Ángel, Rosendo
dc.creatorLópez-Muñoz, Francisco J.
dc.creatorPellicer, Francisco
dc.date.accessioned2017-06-29T06:02:47Z
dc.date.available2017-06-29T06:02:47Z
dc.date.issued2008es_ES
dc.identifier559es_ES
dc.identifier.issn1090-3801es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5246
dc.identifier.urihttps://doi.org/10.1016/j.ejpain.2007.08.008es_ES
dc.language.isoenges_ES
dc.relation12 (5) 535-543 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.mesh2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine-Pharmacologyes_ES
dc.subject.meshAfferent pathways-Physiopathologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshApomorphine-Analogs & derivativeses_ES
dc.subject.meshApomorphine-Pharmacologyes_ES
dc.subject.meshBenzazepines-Pharmacologyes_ES
dc.subject.meshCerebral cortex-Physiologyes_ES
dc.subject.meshChronic diseasees_ES
dc.subject.meshDopamine-Physiologyes_ES
dc.subject.meshDopamine agonists-Pharmacologyes_ES
dc.subject.meshDopamine antagonists-Pharmacologyes_ES
dc.subject.meshHot temperature-Adverse effectses_ES
dc.subject.meshMalees_ES
dc.subject.meshMicroinjectionses_ES
dc.subject.meshModels, Neurologicales_ES
dc.subject.meshNeuralgia-Physiopathologyes_ES
dc.subject.meshNociceptors-Physiologyes_ES
dc.subject.meshPain-Physiopathologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, Dopamine D1-Drug effectses_ES
dc.subject.meshReceptors, Dopamine D1-Physiologyes_ES
dc.subject.meshReceptors, Dopamine D2-Drug effectses_ES
dc.subject.meshReceptors, Dopamine D2-Physiologyes_ES
dc.subject.meshReceptors, N-Methyl-D-Aspartate-Physiologyes_ES
dc.subject.meshSciatic Neuropathy-Physiopathologyes_ES
dc.subject.meshSelf mutilation-Physiopathologyes_ES
dc.subject.meshSpiperone-Pharmacologyes_ES
dc.titleDopamine receptors in the anterior insular cortex modulate long-term nociception in the rates_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de Fuente, Camino a Xochimilco 101, San Lorenzo Huipulco, Tlalpan, México D.F. CP. 14370, Mexico.es_ES
dc.relation.jnabreviadoEUR J PAINes_ES
dc.relation.journalEuropean Journal of Paines_ES
dc.identifier.placeEnglandes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1532-2149es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaThe rostral agranular insular cortex (RAIC) receives dopaminergic projections from the mesolimbic system, which has been involved in the modulation of nociceptive processes. In this study we determined the contribution of dopamine D(1) and D(2) receptors in the RAIC regarding nociception processing in a neuropathic pain model, as well as inflammatory articular nociception measured as pain-induced functional impairment in the rat (PIFIR). Microinjection of vehicle or substances into the RAIC was performed after the induction of nociception. The groups were treated with: a dopamine D(1) receptor antagonist (SCH-23390), a dopamine D(1) receptor agonist (SKF-38393), a dopamine D(2) receptor agonist (TNPA) and a dopamine D(2) receptor antagonist (spiperone). Chronic nociception, induced by denervation, was measured by the autotomy score in which onset and incidence were also determined. The SCH-23390 and TNPA groups showed a decrease in the autotomy score and a delay on the onset as compared to control, whereas the PIFIR groups did not show statistical differences. This work shows the differential role of dopamine receptors within the RAIC in which the activation of D(2) or the blockade of D(1) receptors elicit antinociception.es_ES
dc.subject.kwDopaminaes_ES
dc.subject.kwBenzazepinaes_ES
dc.subject.kwRatas Winstares_ES
dc.subject.kwDolores_ES
dc.subject.koDopaminees_ES
dc.subject.koBenzazepinees_ES
dc.subject.koWinstar ratses_ES
dc.subject.koPaines_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem