Mostrar el registro sencillo del ítem

Association analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patients

dc.creatorAguirre, A.J.
dc.creatorApiquián, R.
dc.creatorFresán, A.
dc.creatorCruz-Fuentes, C.
dc.date.accessioned2017-06-29T06:02:13Z
dc.date.available2017-06-29T06:02:13Z
dc.date.issued2007es_ES
dc.identifier533es_ES
dc.identifier.issn0165-1781es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5220
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2006.12.011es_ES
dc.language.isoenges_ES
dc.relation153 (3) 209-215 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshAdultes_ES
dc.subject.meshBipolar Disorder-diagnosises_ES
dc.subject.meshBipolar Disorder-geneticses_ES
dc.subject.meshDepressive Disorder, Major-diagnosises_ES
dc.subject.meshDepressive Disorder, Major-geneticses_ES
dc.subject.meshEthnic Groups-geneticses_ES
dc.subject.meshExons-geneticses_ES
dc.subject.meshFemalees_ES
dc.subject.meshGene Frequencyes_ES
dc.subject.meshGenetic Predisposition to Diseasees_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHaplotypeses_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMexico-ethnologyes_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshMinisatellite Repeats-geneticses_ES
dc.subject.meshPolymorphism, Genetic-geneticses_ES
dc.subject.meshPsychotic Disorders-diagnosises_ES
dc.subject.meshPsychotic Disorders-geneticses_ES
dc.subject.meshReceptors, Dopamine D4-geneticses_ES
dc.subject.meshRisk Factorses_ES
dc.subject.meshSchizophrenia, Paranoid-diagnosises_ES
dc.subject.meshSchizophrenia, Paranoid-geneticses_ES
dc.titleAssociation analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patientses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética Psiquiátrica, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría "Ramón de la Fuente", Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, cp 14370 D.F., México.es_ES
dc.relation.jnabreviadoPSYCHIATRY RESes_ES
dc.relation.journalPsychiatry Researches_ES
dc.identifier.placeIrelandes_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7123es_ES
dc.identifier.doi10.1016/j.psychres.2006.12.011es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaIn this study, we investigated whether polymorphisms of the dopamine D4 receptor (DRD4) gene were associated with psychotic symptomatology rather than with a unique diagnosis such as schizophrenia. A number of association studies between the DRD4 gene 48 bp-VNTR polymorphism at exon 3 and psychotic disorders have been reported, but the results have been controversial. Both 48 bp-VNTR and the 12 bp-VNTR (at exon 1) polymorphisms of this gene were analyzed in a group of 149 unrelated Mexican subjects with a diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, major depression and bipolar disorder, both with psychotic symptoms, brief psychotic disorder, delusional disorder and non-specific psychotic disorder, and in 169 individuals free of psychiatric illnesses. There were no differences in allele or genotype frequencies between groups for the 12 bp-VNTR polymorphisms. However, a significant excess of ‘rare’ alleles (3-, 5-, 6- and 8-48 bp repeats alleles) was found in the group of psychotics. Moreover, haplotypes 3-A1, 5-A1, 6-A1 and 8-A1 were significantly more frequently associated with cases. This positive association supports a role of this molecule as a genetic risk factor in psychotic disorders.es_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem