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Changes in Proenkephalin mRNA expression in forebrain areas after amphetamine-induced behavioural sensitization

dc.creatorMorales-Mulia, M
dc.creatorPanayi, F
dc.creatorLambás-Señas, L
dc.creatorScarna, H
dc.creatorMéndez, M.
dc.date.accessioned2017-06-29T06:02:10Z
dc.date.available2017-06-29T06:02:10Z
dc.date.issued2007es_ES
dc.identifier530es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5217
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2007.04.019es_ES
dc.language.isoenges_ES
dc.relation87 (2) 232-240 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAutoradiographyes_ES
dc.subject.meshBehavior, Animal-drug effectses_ES
dc.subject.meshCaudate Nucleus-drug effectses_ES
dc.subject.meshCaudate Nucleus-metabolismes_ES
dc.subject.meshCentral Nervous System Stimulants-pharmacologyes_ES
dc.subject.meshDextroamphetamine-pharmacologyes_ES
dc.subject.meshEnkephalins-biosynthesises_ES
dc.subject.meshEnkephalins-physiologyes_ES
dc.subject.meshIn Situ Hybridizationes_ES
dc.subject.meshMalees_ES
dc.subject.meshNucleus Accumbens-drug effectses_ES
dc.subject.meshNucleus Accumbens-metabolismes_ES
dc.subject.meshProsencephalon-metabolismes_ES
dc.subject.meshProtein Precursors-biosynthesises_ES
dc.subject.meshPutamen-drug effectses_ES
dc.subject.meshPutamen-metabolismes_ES
dc.subject.meshRNA, Messenger-biosynthesises_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Sprague-Dawleyes_ES
dc.subject.meshSynaptic Transmission-physiologyes_ES
dc.titleChanges in Proenkephalin mRNA expression in forebrain areas after amphetamine-induced behavioural sensitizationes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Neuroquímica, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente, Calzada México Xochimilco 101, Col. San Lorenzo Huipulco, 14370 México D.F., Mexicoes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.pbb.2007.04.019es_ES
dc.description.monthJun-Jules_ES
dc.description.abstractotrodiomaAcute and repeated psychostimulant administration induces a long-lasting enhanced behavioural response to a subsequent drug challenge, known as behavioural sensitization. This phenomenon involves persistent neurophysiological adaptations, which may lead to drug addiction. Brain dopaminergic pathways have been implicated as the main neurobiological substrates of behavioural sensitization, although other neurotransmitters and neuromodulators may also participate. In order to investigate a possible involvement of opioid systems in amphetamine (AMPH) behavioural sensitization, we studied the AMPH-induced changes in Proenkephalin (Pro-Enk) mRNA expression in forebrain areas in both drug-naïve and AMPH-sensitized rats. Male Sprague-Dawley rats were sensitized to AMPH by means of a single AMPH (1 mg/kg s.c.) injection and the same dose was injected 7 days later to assess the expression of sensitization. Pro-Enk mRNA levels were evaluated by in situ hybridization in coronal brain sections. AMPH injection induced an increase in Pro-Enk mRNA expression in the nucleus accumbens and the medial-posterior caudate-putamen in drug-naïve rats. Challenge with AMPH to rats injected 1 week earlier with AMPH induced motor sensitization and increased and decreased Pro-Enk mRNA expression in the prefrontal cortex and the anterior medial caudate-putamen, respectively. Our results suggest that alterations in cortical and striatal enkephalinergic systems could contribute to the expression of AMPH behavioural sensitization.es_ES


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