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Association study of MAO-A and DRD4 genes in schizophrenic patients with aggressive behavior

dc.creatorFresán, Ana
dc.creatorCamarena, Beatriz
dc.creatorApiquián, Rogelio
dc.creatorAguilar, Alejandro
dc.creatorUrraca, Nora
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-29T06:02:09Z
dc.date.available2017-06-29T06:02:09Z
dc.date.issued2007es_ES
dc.identifier528es_ES
dc.identifier.issn0302-282Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5215
dc.identifier.urihttps://doi.org/10.1159/000106477es_ES
dc.language.isoenges_ES
dc.relation55 (3-4) 171-175 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdultes_ES
dc.subject.meshAgedes_ES
dc.subject.meshAggressiones_ES
dc.subject.meshChi-Square Distributiones_ES
dc.subject.meshFemalees_ES
dc.subject.meshGene Frequencyes_ES
dc.subject.meshGenetic Predisposition to Diseasees_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshMonoamine Oxidase-geneticses_ES
dc.subject.meshPolymorphism, Genetic-geneticses_ES
dc.subject.meshReceptors, Dopamine D4-geneticses_ES
dc.subject.meshSchizophrenia-geneticses_ES
dc.subject.meshSchizophrenia-physiopathologyes_ES
dc.subject.meshStatistics, Nonparametrices_ES
dc.titleAssociation study of MAO-A and DRD4 genes in schizophrenic patients with aggressive behaviores_ES
dc.typearticlees_ES
dc.contributor.affiliationClinical Research Division, National Institute of Psychiatry Ramón de la Fuente, Mexico City, Mexico.es_ES
dc.relation.jnabreviadoNEUROPSYCHOBIOLOGYes_ES
dc.relation.journalNeuropsychobiologyes_ES
dc.identifier.placeSuizaes_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1423-0224es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaGenes involved in dopamine neurotransmission are interesting candidates to be analyzed in schizophrenia and aggressive behavior. Therefore, we analyzed the functional polymorphisms of the dopamine receptor D4 (DRD4) and monoamine oxidase A (MAO-A) genes in a sample of 71 schizophrenic patients assessed with the Overt Aggression Scale to measure aggressive behavior. CLUMP analysis of the DRD4 48-bp repeat-exon III polymorphism in schizophrenic patients showed significant differences between the aggressive behavior and the nonaggressive groups (T1 = 18.77, d.f. = 6, p = 0.0046; T3 = 6.54, p = 0.0195). However, analysis of the promoter polymorphism of the MAO-A gene revealed no significant association between aggressive and nonaggressive patients. Finally, analysis of Overt Aggression Scale dimensions exhibited significant differences for the DRD4 and MAO-A genes. Our preliminary findings suggest that the DRD4 and MAO-A genes may be involved in aggressive schizophrenic patients.es_ES
dc.subject.kwGen receptor de dopamina D4es_ES
dc.subject.kwAgresividades_ES
dc.subject.kwGen de monoamino oxidasa Aes_ES
dc.subject.kwEsquizofreniaes_ES
dc.subject.koDopamine Receptor D4 genees_ES
dc.subject.koAggressivenesses_ES
dc.subject.koMonoamine oxidase A genees_ES
dc.subject.koSchizophreniaes_ES


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