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Association study between the dopamine receptor D4 gene and obsessive-compulsive disorder

dc.creatorCamarena, Beatriz
dc.creatorLoyzaga, Cristina
dc.creatorAguilar, Alejandro
dc.creatorWeissbecker, Karen
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-29T06:02:00Z
dc.date.available2017-06-29T06:02:00Z
dc.date.issued2007es_ES
dc.identifier518es_ES
dc.identifier.issn0924-977Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5205
dc.identifier.urihttps://doi.org/10.1016/j.euroneuro.2006.08.001es_ES
dc.language.isoenges_ES
dc.relation17 (6) 406-409 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAssociation study between the dopamine receptor D4 gene and obsessive-compulsive disorderes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Psychiatric Genetics, National Institute of Psychiatry Ramón de la Fuente, Mexico D.F. 14370, Mexicoes_ES
dc.relation.jnabreviadoEUR NEUROPSYCHOPHARMACOLes_ES
dc.relation.journalEuropean Neuropsychopharmacologyes_ES
dc.identifier.placeNetherlandses_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7862es_ES
dc.identifier.doi10.1016/j.euroneuro.2006.08.001es_ES
dc.description.monthMay-Junes_ES
dc.description.abstractotrodiomaPharmacological and neuroanatomical evidence suggest the involvement of the dopaminergic system in obsessive–compulsive disorder (OCD). Analysis of the 48-bp dopamine receptor D4 (DRD4) gene polymorphism in a sample of 210 OCD patients and 202 healthy control subjects showed a significant association (_2 = 27.5, df = 6, p = 0.0003). This difference was attributable to a lower frequency of allele 4R in OCD patients compared with the control group (_2 = 9.33, p = 0.0027). However, we did not replicate previous findings of an association between the 7R allele and OCD patients with tics. Finally, we analyzed a sub-sample of 86 OCD families. E-TDT analysis in 70 informative parents did not confirm the association observed in our case–control analysis. In conclusion, the current study cannot exclude an association betweenDRD4 gene and OCD in the largest sample analyzed. However, further studies will be required to confirm if the DRD4 gene is involved in the pathogenesis of this disorder.es_ES
dc.subject.kwTOCes_ES
dc.subject.kwDopamina gen del receptor D4es_ES
dc.subject.kwGéneroes_ES
dc.subject.kwTicses_ES
dc.subject.koOCDes_ES
dc.subject.koDopamine D4 receptor genees_ES
dc.subject.koGenderes_ES
dc.subject.koTicses_ES


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