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Immune variations in bipolar disorder: phasic differences

dc.creatorOrtíz-Domínguez, Abigail
dc.creatorHernández, María Eugenia
dc.creatorBerlanga, Carlos
dc.creatorGutiérrez-Mora, Doris
dc.creatorMoreno, Julia
dc.creatorHeinze, Gerhard
dc.creatorPavón, Lenin
dc.date.accessioned2017-06-29T06:01:55Z
dc.date.available2017-06-29T06:01:55Z
dc.date.issued2007es_ES
dc.identifier513es_ES
dc.identifier.issn1398-5647es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5200
dc.identifier.urihttps://doi.org/10.1111/j.1399-5618.2007.00493.xes_ES
dc.language.isoenges_ES
dc.relation9 (6) 596-602 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdultes_ES
dc.subject.meshBipolar Disorder-bloodes_ES
dc.subject.meshBipolar Disorder-immunologyes_ES
dc.subject.meshBipolar Disorder-physiopathologyes_ES
dc.subject.meshDepression-immunologyes_ES
dc.subject.meshDown-Regulationes_ES
dc.subject.meshFemalees_ES
dc.subject.meshHumanses_ES
dc.subject.meshInterleukin-es_ES
dc.subject.meshbeta-bloodes_ES
dc.subject.meshInterleukin-2-bloodes_ES
dc.subject.meshInterleukin-4-bloodes_ES
dc.subject.meshInterleukin-6-bloodes_ES
dc.subject.meshMalees_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshPsychiatric Status Rating Scaleses_ES
dc.subject.meshTumor Necrosis Factor-alpha-bloodes_ES
dc.subject.meshUp-Regulationes_ES
dc.titleImmune variations in bipolar disorder: phasic differenceses_ES
dc.typearticlees_ES
dc.contributor.affiliationBipolar Disorder Clinic, National Institute of Psychiatry, Mexico City, Mexico.es_ES
dc.contributor.emaillkuriaki@imp.edu.mxes_ES
dc.relation.jnabreviadoBIPOLAR DISORDes_ES
dc.relation.journalBipolar Disorderses_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1399-5618es_ES
dc.identifier.doi10.1111/j.1399-5618.2007.00493.xes_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaOBJECTIVES: To characterize the immunological variations of patients with a bipolar disorder (BD) diagnosis in manic (BDm) and depressive (BDd) phases, by the quantification of the serum levels of interleukin (IL)-1beta, -2, -4, -6 and tumor necrosis factor alpha (TNF-alpha). METHODS: Twenty physically healthy patients with a BD type I diagnosis and 33 matched controls were studied, after giving informed consent. The inclusion criteria included at least three weeks without any kind of psychopharmacological treatment, Young Mania Rating Scale score > or =20 for BDm (n = 10) and Hamilton Depression Rating Scale score > or =21 for BDd patients (n = 10). Exclusion criteria included any infectious diseases, allergies or any other kind of medical illness that required treatment with immunosuppressors, as well as any other diagnosis in Axis I. Physical and laboratory examinations were performed to rule out any clinical illness. Enzyme-linked immunosorbent assay (ELISA) was used to analyze the serum cytokines concentration. RESULTS: BD patients, when compared to controls, showed significant differences (p < or = 0.05) in the serum levels of the measured cytokines. The sub-group of BDd patients showed an increase in IL-6 and TNF-alpha, as well as a decrease in IL-2 concentration. The BDm sub-group, on the other hand, showed an increase in TNF-alpha and IL-4 values, with a low concentration of IL-1 and IL-2. The comparison between both sub-groups suggests that there is a distinctive cytokine pattern for the specific phases of the disorder: for mania, we found a high IL-4 and low IL-1beta and IL-6 concentration, while in the depressive phase, the inverse pattern was found. CONCLUSIONS: Our results show the existence of phasic differences in the serum levels of cytokines in BD.es_ES


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