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A novel bivalent morphine/heroin vaccine that prevents relapse to heroin addiction in rodents

dc.creatorAntón, Benito
dc.creatorLeff, Philippe
dc.date.accessioned2017-06-29T04:40:37Z
dc.date.available2017-06-29T04:40:37Z
dc.date.issued2006es_ES
dc.identifier507es_ES
dc.identifier.issn0264-410Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5194
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2006.01.047es_ES
dc.language.isoenges_ES
dc.relation24 (16) 3232-3240 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleA novel bivalent morphine/heroin vaccine that prevents relapse to heroin addiction in rodentses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratory of Molecular Neurobiology and Addictive Neurochemistry, National Institute of Psychiatry, Ramón de la Fuente Muñiz, Calz., México-Xochimilco #101es_ES
dc.contributor.emailantonpb@imp.edu.mxes_ES
dc.relation.jnabreviadoVACCINEes_ES
dc.relation.journalVaccinees_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.vaccine.2006.01.047es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaBoth pre-clinical and clinical studies make feasible the use of vaccines as novel therapeutic medications to treat drug addiction. No reports to date have shown the development of structural models of opiate candidate vaccines for treating human addiction to such compounds. Here we report on the initial development of a novel structural formulation of a bi-valent vaccine against morphine/heroin. This vaccine was able to trigger and establish a high titer antibody response to haptenized drug with antibodies displaying equivalent specificities for both morphine and heroin. Such antibodies did not cross-recognize structurally dissimilar opiate medications. Furthermore, the evaluation of the potential therapeutic effectiveness of this vaccine was targeted to relapse prevention using a schedule of heroin delivery in the rat self-administration model. Antibodies against heroin blocked its reinforcing effects in rodents. The type of carrier protein used in this vaccine allows further evaluation of its potential therapeutic value for preventing relapse to heroin addiction in humans.es_ES
dc.subject.koVaccinees_ES
dc.subject.koMorphine-heroines_ES
dc.subject.koImmunoprotectiones_ES
dc.subject.koOpiateses_ES
dc.subject.koActive inmunizationes_ES
dc.subject.koPreventiones_ES
dc.subject.koAddictiones_ES


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