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Phosphorylation-dephosphorylation imbalance of cytoskeletal associated proteins in neurodegenerative diseases

dc.creatorBenítez-King, G
dc.creatorOrtiz-López, L
dc.creatorMorales-Mulia, S
dc.creatorJiménez-Rubio, G
dc.creatorRamírez-Rodríguez, G
dc.creatorMeza, I.
dc.date.accessioned2017-06-29T04:39:49Z
dc.date.available2017-06-29T04:39:49Z
dc.date.issued2006es_ES
dc.identifier500es_ES
dc.identifier.issn1574-8898es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5187
dc.identifier.urihttp://doi.org/10.2174/157488906777452776es_ES
dc.language.isoenges_ES
dc.relation1 (2) 219-230 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePhosphorylation-dephosphorylation imbalance of cytoskeletal associated proteins in neurodegenerative diseaseses_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría, Departamento de Neurofarmacología, Subdirección de Investigaciones Clínicas, México, D.F., Méxicoes_ES
dc.contributor.emailbekin@imp.edu.mxes_ES
dc.relation.jnabreviadoRECENT PAT CNS DRUG DISCOVes_ES
dc.relation.journalRecent patents on CNS drug discoveryes_ES
dc.identifier.placeEmiratos Ärabes Unidoses_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaNeurons are highly asymmetric cells, specialized to transmit and receive information through axons and dendrites. Neuronal morphology is determined by a particular cytoskeletal organization that provides the framework for distinct axonal and dendritic structures. Dynamic cytoskeletal rearrangements occur during neurite outgrowth, neuronal plasticity and synaptic connectivity. In this work, we summarize the evidences that support that these dynamic changes are mainly governed by phosphorylation-dephosphorylation equilibrium of cytoskeleton and cytoskeletal-associated proteins. In addition, we describe evidence supporting that in neurodegeneration an imbalance of this equilibrium occurs, followed by disarray of the cytoskeleton in axons and dendrites with the consequent disruption of synaptic connectivity. Finally we discuss current strategies and patents that could contribute to re-establish a balance in the brain of patients with dementia.es_ES


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