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Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involvement of the GABA/benzodiazepine receptor complex

dc.creatorLópez-Rubalcava, C.
dc.creatorPiña-Medina, B.
dc.creatorEstrada-Reyes, R.
dc.creatorHeinze, G.
dc.creatorMartínez-Vázquez, M.
dc.date.accessioned2017-06-29T04:39:30Z
dc.date.available2017-06-29T04:39:30Z
dc.date.issued2006es_ES
dc.identifier497es_ES
dc.identifier.issn0024-3205es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5184
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2005.05.078es_ES
dc.language.isoenges_ES
dc.relation78 (7) 730-737 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involvement of the GABA/benzodiazepine receptor complexes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Centro de Investigación y Estudios Avanzados (CINVESTAV). Calzada de los Tenorios 235, Col. Granjas Coapa. C.P. 14330, México D.F., Méxicoes_ES
dc.contributor.emailclopezr@cinvestav.mxes_ES
dc.relation.jnabreviadoLIFE SCIes_ES
dc.relation.journalLife Scienceses_ES
dc.identifier.placeOxfordes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.lfs.2005.05.078es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaA hexane extract of leaves of Annona cherimolia produced anxiolytic-like actions when administered to mice and tested in two animal models of anxiety: the mouse avoidance exploratory behavior and the burying behavior tests. In order to discard unspecific drug-actions on general activity, all treatments studied in the anxiety paradigms were also analyzed in the open field test. Results showed that A. cherimolia induced anxiolytic-like actions at the doses of 6.25, 12.5, 25.0 and 50.0 mg/kg. Picrotoxin (0.25 mg/kg), a GABA-gated chloride ion channel blocker, antagonized the anxiolytic-like actions of A. cherimolia, while a sub-effective dose of muscimol (0.5 mg/kg), a selective GABAA receptor agonist, facilitated the effects of a sub-optimal dose of A. cherimolia (3.12 mg/kg). Thus, the involvement of the GABAA receptor complex in the anxiolytic-like actions of A. cherimolia hexane extract is suggested. In addition the extract was also able to enhance the duration of sodium pentobarbital induced sleeping time. Taken together, results indicate that the hexane extract of A. cherimolia has depressant activity on the Central Nervous System and could interact with the GABAA receptor complex. On the other hand, the chromatographic separation of this extract led to the isolation of palmitone, and h-sitosterol as major constituents. In addition a GC-MS study of some fractions revealed the presence of several compounds such h-cariophyllene, h-selinene, a-cubebene, and linalool that have been reported to show effects on behavior that could explain some of the extract effects.es_ES
dc.subject.kwAnnona cherimoliaes_ES
dc.subject.kwReceptor GABA Aes_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwMuscimoles_ES
dc.subject.kwPicrotoxinaes_ES
dc.subject.koAnnona cherimoliaes_ES
dc.subject.koGABAA receptores_ES
dc.subject.koAnxietyes_ES
dc.subject.koMuscimoles_ES
dc.subject.koPicrotoxines_ES


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