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Melatonin as a cytoskeletal modulator: implications for cell physiology and disease.

dc.creatorBenítez-King, Gloria
dc.date.accessioned2017-06-29T04:39:24Z
dc.date.available2017-06-29T04:39:24Z
dc.date.issued2006es_ES
dc.identifier496es_ES
dc.identifier.issn0742-3098es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5183
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2005.00282.xes_ES
dc.language.isoenges_ES
dc.relation40 (1) 1-9 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleMelatonin as a cytoskeletal modulator: implications for cell physiology and disease.es_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexicoes_ES
dc.contributor.emailbekin@imp.edu.mxes_ES
dc.relation.jnabreviadoJ PINEAL RESes_ES
dc.relation.journalJournal of pineal researches_ES
dc.identifier.placeDinamarcaes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1111/j.1600-079X.2005.00282.xes_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaThe cytoskeleton is a phylogenetically well-preserved structure that plays a key role in cell physiology. Dynamic and differential changes in cytoskeletal organization occur in cellular processes according to the cell type and the specific function. In neurons, microtubules, microfilaments and intermediate filament (IF) rearrangements occur during axogenesis, and neurite formation which eventually differentiate into axons and dendrites to constitute synaptic patterns of connectivity. In epithelial cells, dynamic modifications occur in the three main cytoskeletal components and phosphorylation of cytoskeletal associated proteins takes place during the formation of the epithelial cell monolayer that eventually will transport water. In pathological processes such as neurodegenerative and psychiatric diseases an abnormal cytoskeletal organization occurs. Melatonin, the main product secreted by pineal gland during dark phase of the photoperiod, is capable of influencing microfilament, microtubule and IF organization by acting as a cytoskeletal modulator. In this paper we will summarize the evidence which provides the data that melatonin regulates cytoskeletal organization and we describe recent findings, which indicate that melatonin effects on microfilament rearrangements in stress fibers are involved in the mechanism by which the indole synchronizes water transport in kidney-derived epithelial cells. In addition, we review recent data, which indicates that melatonin protects the neuro-cytoskeletal organization from damage caused by free radicals contributing to cell survival, in addition to the already described mechanism elicited by the indole to prevent apoptosis and to scavenge free radicals. Moreover, we discuss the implications of an altered cytoskeletal organization for neurodegenerative and psychiatric illnesses and its re-establishment by melatonin.es_ES


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