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Th2 cytokine response in Major Depressive Disorder patients before treatment

dc.creatorPavón, L.
dc.creatorSandoval-López, G.
dc.creatorHernández, M. Eugenia
dc.creatorLoría, F.
dc.creatorEstrada, I.
dc.creatorPérez, M.
dc.creatorMoreno, J.
dc.creatorAvila, U.
dc.creatorLeff, P.
dc.creatorAntón, B.
dc.creatorHeinze, G.
dc.date.accessioned2017-06-29T04:39:19Z
dc.date.available2017-06-29T04:39:19Z
dc.date.issued2006es_ES
dc.identifier495es_ES
dc.identifier.issn0165-5728es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5182
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2005.08.014es_ES
dc.language.isoenges_ES
dc.relation172 (1-2) 156-165 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleTh2 cytokine response in Major Depressive Disorder patients before treatmentes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Psychoimmunology, National Institute of Psychiatry Ramón de la Fuente, Méxicoes_ES
dc.relation.jnabreviadoJ NEUROIMMUNOLes_ES
dc.relation.journalJournal of neuroimmunologyes_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.jneuroim.2005.08.014es_ES
dc.description.monthMares_ES
dc.description.abstractotrodioman Major Depressive Disorder (MDD), the neuroendocrine and immune systems interactions are impaired. We investigated the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group. The MDD subjects showed higher levels of cortisol and TNF-alpha, increased CD3+CD8+ and NK percentages, diminished B cell counts and no significant variations in CD3+CD4+ lymphocyte. Moreover, higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group. Overall, we propose that all these changes could be related to the elevated cortisol levels seen in the MDD patients. Further studies are necessary to explore these findings and its implication in future therapeutic approach of MDD patients.es_ES


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