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Paraventricular hypothalamic influences on spinal nociceptive processing

dc.creatorCondés-Lara, Miguel
dc.creatorRojas-Piloni, Gerardo
dc.creatorMartínez-Lorenzana, Guadalupe
dc.creatorRodríguez-Jiménez, Javier
dc.creatorLópez Hidalgo, Mónica
dc.creatorFreund-Mercier, Marie José
dc.date.accessioned2017-06-29T04:38:12Z
dc.date.available2017-06-29T04:38:12Z
dc.date.issued2006es_ES
dc.identifier485es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5172
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2006.01.050es_ES
dc.language.isoenges_ES
dc.relation1081 (1) 126-137 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleParaventricular hypothalamic influences on spinal nociceptive processinges_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, México; Instituto Nacional de Psiquiatría “Ramón de la Fuente” México D.F., Méxicoes_ES
dc.contributor.emailcondes@servidor.unam.mxes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.brainres.2006.01.050es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaOxytocin properties have been studied in different experimental models in order to obtain evidence for its analgesic properties. The analgesic effect of an oxytocinergic pathway descending from the hypothalamus reaching the dorsal horn of the spinal cord has been studied. In anesthetized rats, we recorded single units at the L4–L5 spinal dorsal horn level and stimulated the peripheral receptive field. The evoked responses were classified according to their latencies in A-beta, A-delta, C fibers, and postdischarge. We used these responses to evaluate the effects of electrical stimulation of the paraventricular nucleus (PV) of the hypothalamus.We observed a selective blockage of A-delta and C fibers related to the duration of the train stimulus duration. Similar effects were observed when oxytocin (OT) was applied directly on the spinal cord. The effects of OT and of PV electrical stimulation were reversed in a dose-dependent manner by application of the specific OT antagonist (OTA). These effects were observed in cells with reduced wind-up and cells displaying a clear wind-up response to peripheral stimulation. Superficial and deeper cells in the dorsal spinal cord were involved. The recorded cells were marked by pontamine blue iontophoretic injection after each cell recording, and their histological locations were specified. In order to obtain a behavioral correlation, we used rats with a loose ligature of the sciatic nerve and a chronic intrathecal catheter reaching the L4–L5 spinal cord level. We tested the hyperalgesia and allodynia of these animals using von Frey filaments and the application of acetone to the hind paws. Our results show a significant reduction in the mechanical and thermal test after the administration of 15 _l of 10_6 M OT. Our electrophysiological, pharmacological, and behavioral results point out a clear OT antialgesic effect. The results are discussed on the basis of a previous work showing an OT blockage of glutamate activation. The paraventricular hypothalamic descending OT pathway is proposed as an interesting mechanism producing analgesia.es_ES
dc.subject.kwOxitocinaes_ES
dc.subject.kwAntianalgésicoes_ES
dc.subject.kwAntagonista de oxitocinaes_ES
dc.subject.kwEstimulación eléctrica praventriculares_ES
dc.subject.koOxytocines_ES
dc.subject.koAntialgesices_ES
dc.subject.koOxytocin antagonistes_ES
dc.subject.koPraventricular electrical stimulationes_ES


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