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Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase II activity in rat limbic regions

dc.creatorDe Gortari, P.
dc.creatorCisneros, M.
dc.creatorJoseph-Bravo, P.
dc.date.accessioned2017-06-29T04:37:01Z
dc.date.available2017-06-29T04:37:01Z
dc.date.issued2005es_ES
dc.identifier472es_ES
dc.identifier.issn0167-0115es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5160
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2004.11.002es_ES
dc.language.isoenges_ES
dc.relation127 (1-3) 141-150 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleChronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase II activity in rat limbic regionses_ES
dc.typearticlees_ES
dc.contributor.affiliationDivisión de Investigación en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, C.P. 14370, México D.F., México.es_ES
dc.contributor.emailgortari@imp.edu.mxes_ES
dc.relation.jnabreviadoREGUL PEPTes_ES
dc.relation.journalRegulatory Peptideses_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-1686es_ES
dc.identifier.doi10.1016/j.regpep.2004.11.002es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaThyrotropin-releasing hormone (TRH), its receptors and inactivating enzyme (PPII) are present in limbic regions. Nutritional changes or acute ethanol administration in male rats differentially modulate TRH or PPII expression. Chronic ethanol effect was studied in male (3, 6 and 8 weeks) and female rats (6 weeks) including naïve and pair-fed (glucose) groups. Daily solid food and liquid intake, serum TSH and corticosterone, TRH content and PPII activity in limbic regions, were quantified. Gender differences were found in ethanol and total caloric intake and body weight gain, TSH and corticosterone levels. Ethanol consumption decreased TRH content and PPII activity in frontal cortex of male rats after 3–6 weeks. In contrast, glucose ingestion altered, by the third week, TRH content in amygdala, hippocampus, hypothalamus and nucleus accumbens, PPII activity in hippocampus and frontal cortex; by the sixth week, TRH content in amygdala and n. accumbens of male and females. Withdrawal at 24 h after 3-week ethanol ingestion decreased TRH content in amygdala and PPII activity in n. accumbens, while withdrawal from glucose reverted some of the effects produced by chronic glucose ingestion. Variations in TRH content or PPII activity support a region specific involvement of TRH neurons that depend on the treatmentes_ES
dc.subject.koAdrenal Cortex Hormoneses_ES
dc.subject.kobloodes_ES
dc.subject.koAminopeptidaseses_ES
dc.subject.kometabolismes_ES
dc.subject.koAnimalses_ES
dc.subject.koDrinkinges_ES
dc.subject.koEatinges_ES
dc.subject.koEthanol*es_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koEthanol*es_ES
dc.subject.kometabolismes_ES
dc.subject.koFemalees_ES
dc.subject.koGlucose*es_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koGlucose*es_ES
dc.subject.kometabolismes_ES
dc.subject.koLimbic Systemes_ES
dc.subject.koanatomy & histologyes_ES
dc.subject.koLimbic Systemes_ES
dc.subject.kometabolismes_ES
dc.subject.koMalees_ES
dc.subject.koPyrrolidonecarboxylic Acides_ES
dc.subject.koanalogs & derivativeses_ES
dc.subject.koPyrrolidonecarboxylic Acides_ES
dc.subject.kometabolismes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koThyrotropines_ES
dc.subject.kobloodes_ES
dc.subject.koThyrotropin-Releasing Hormonees_ES
dc.subject.kometabolismes_ES
dc.subject.koAdrenal Cortex Hormoneses_ES
dc.subject.koThyrotropin-Releasing Hormonees_ES
dc.subject.koGlucosees_ES
dc.subject.koEthanoles_ES
dc.subject.koThyrotropines_ES
dc.subject.koPyrrolidonecarboxylic Acides_ES
dc.subject.koAminopeptidaseses_ES
dc.subject.kopyroglutamyl-peptidase IIes_ES


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