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Repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex increases tolerance to human experimental pain

dc.creatorGraff-Guerrero, Ariel
dc.creatorGonzález-Olvera, Jorge
dc.creatorFresán, Ana
dc.creatorGómez-Martín, Diana
dc.creatorMéndez-Nuñez, Juan Carlos
dc.creatorPellicer, Francisco
dc.date.accessioned2017-06-29T04:36:06Z
dc.date.available2017-06-29T04:36:06Z
dc.date.issued2005es_ES
dc.identifier463es_ES
dc.identifier.issn0926-6410es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5152
dc.identifier.urihttps://doi.org/10.1016/j.cogbrainres.2005.05.002es_ES
dc.language.isoenges_ES
dc.relation25 (1) 153-160 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshSensory systemses_ES
dc.subject.meshPain modulationes_ES
dc.subject.meshAnatomy and physiologyes_ES
dc.titleRepetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex increases tolerance to human experimental paines_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente, Dirección de Investigaciones en Neurociencias (Lab. Neurofisiología Integrativa) Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Del. Tlalpan, 14370, México, D.F.y Centre for Addiction and Mental Health, PET Centre, Toronto, Ontario, Canadaes_ES
dc.contributor.emailagraff@imp.edu.mxes_ES
dc.relation.jnabreviadoCIGN BRAIN RESes_ES
dc.relation.journalCognitive BrainResearches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.cogbrainres.2005.05.002es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaDorsolateral prefrontal cortex (DLPFCx) has been implicated in pain perception and in a pain modulation pathway. However, the precise participation of this region is not completely understood. The aim of this study was to evaluate whether 1 Hz rTMS of DLPFCx modifies threshold and tolerance in experimental pain. The effect of 1 Hz rTMS during 15 min at 100% motor threshold was tested in one hundred and eighty right-handed healthy volunteers, using a parallel-group stimulation design. The stimulation sites were right or left DLPFCx, right or left motor cortex, vertex or sham. rTMS was applied in two experimental contexts: (1) To evaluate its transitory effect (interference or facilitation) during cold pressor threshold (CPTh) and tolerance (CPTt) and (2) to evaluate its long-term effect by stimulating before CPTh, CPTt, pain heat thermal threshold, pain pressure threshold and tolerance. During rTMS of right DLPFCx, an increase in left hand CPTt (mean +/- SD; 17.63 s +/- 5.58 to 30.94 s +/- 14.84, P < 0.001) and in right hand CPTt (18.65 s +/- 6.47 to 26.74 s +/- 11.85, P < 0.001) were shown. No other stimulation site modified any of the pain measures during or after rTMS. These results show that 1 Hz rTMS of right DLPFCx has a selective effect by increasing pain tolerance and also sustains a right hemisphere preference in pain processing.es_ES
dc.subject.kwCorteza prefrontal dorsolaterales_ES
dc.subject.kwEstimulación magnética transcraneal repetitivaes_ES
dc.subject.kwMemoria de trabajoes_ES
dc.subject.kwDolores_ES
dc.subject.kwUmbral del dolores_ES
dc.subject.kwTolerancia al dolores_ES
dc.subject.kwDel fríoes_ES
dc.subject.koDorsolateral prefrontal cortexes_ES
dc.subject.koRepetitive transcranial magnetic stimulationes_ES
dc.subject.koWorking memoryes_ES
dc.subject.koPaines_ES
dc.subject.koPain thresholdes_ES
dc.subject.koPain tolerancees_ES
dc.subject.koCold pressores_ES


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