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Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats

dc.creatorCondés-Lara, Miguel
dc.creatorMaiec, Idil Admed Sh.
dc.creatorDickenson, Anthony H.
dc.date.accessioned2017-06-29T04:35:54Z
dc.date.available2017-06-29T04:35:54Z
dc.date.issued2005es_ES
dc.identifier461es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5150es_ES
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2005.03.020es_ES
dc.language.isoenges_ES
dc.relation1045 (1-2) 124-133 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshSensory systemses_ES
dc.subject.meshPain modulationes_ES
dc.subject.meshPharmacologyes_ES
dc.titleOxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, México; Instituto Nacional de Psiquiatría ‘‘Ramón de la Fuente’’, México D. F., Méxicoes_ES
dc.contributor.emailcondes@servidor.unam.mxes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.brainres.2005.03.020es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaA hypothalamic oxytocinergic-descending pathway that reaches the dorsal horn of the spinal cord has been well documented and recently related to states of pain and analgesia. In order to study the action of the neuropeptide oxytocin (OT) on pain-related responses, we compared dorsal horn neuronal responses to electrical and mechanical stimulation of receptive fields in normal and neuropathic rats. Spinal nerve (L5 and L6) ligation (Chung rats) was used to produce experimental neuropathy. Single unit activity was recorded at the L4–L5 level from neurons identified as wide dynamic range presenting latency responses corresponding to A-beta, A-delta, C fibers and also exhibiting postdischarge, and wind-up. We tested intrathecally applied doses of 0.05, 0.1, 1, 2, 5, 10 I.U. of OT. Minor effects on responses to electrical stimulation were present in normal rats. Mechanical responses evoked by von Frey filaments were slightly reduced in normal animals. In neuropathic rats a dose of 1 I.U. produced a significant reduction in C-fibers and post-discharge activities, and doses of 2 I.U. caused a further, pronounced reduction in post-discharge, wind-up, and input values. However, the most marked change was the post-discharge reduction at 10 and 20 min after OT administration. Mechanical responses were significantly reduced in terms of their discharge rate response in neuropathic rats. The contrasting results obtained in normal and neuropathic rats revealed an important distinction between these animals and indicate that plastic changes occur as a consequence of nerve damage. In neuropathic rats, mechanisms involving ascending noxious information to the paraventricular nuclei and descending OT activities could be altered so sensitizing the OT receptors of the spinal dorsal horn cells and could explain our observations. Our results point out an anti-algesic OT effect in neuropathic rats.es_ES
dc.subject.kwCélulas de la médula espinales_ES
dc.subject.kwDespués de la descargaes_ES
dc.subject.kwTerminares_ES
dc.subject.kwCampo receptivo de estimulaciónes_ES
dc.subject.kwEstados del Dolores_ES
dc.subject.koSpinal cord cellses_ES
dc.subject.koPost-dischargees_ES
dc.subject.koWind-upes_ES
dc.subject.koReceptive field stimulationes_ES
dc.subject.koPain stateses_ES


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