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Chromosome 11-q24 region in Tourette syndrome: association and linkage disequilibrium study in the French Canadian population

dc.creatorDíaz-Anzaldúa, A.
dc.creatorRiviére, J.B.
dc.creatorDubé, M.P.
dc.creatorJoober, R.
dc.creatorSaint-Onge, J.
dc.creatorDion, Y.
dc.creatorLespérance, P.
dc.creatorRicher, F.
dc.creatorChouinard, S.
dc.creatorRouleau, G.A.
dc.date.accessioned2017-06-29T04:35:43Z
dc.date.available2017-06-29T04:35:43Z
dc.date.issued2005es_ES
dc.identifier459es_ES
dc.identifier.issn1552-4825es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5148
dc.identifier.urihttps://doi.org/10.1002/ajmg.a.30928es_ES
dc.language.isoenges_ES
dc.relation138A (3) 225-228 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleChromosome 11-q24 region in Tourette syndrome: association and linkage disequilibrium study in the French Canadian populationes_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente, Mexico City, Mexico.es_ES
dc.relation.jnabreviadoAM J MED GENET Aes_ES
dc.relation.journalAmerican Journal of Medical Geneticses_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaPrevious studies have found association and linkage between Tourette syndrome (TS) and markers at the 11q24 region, mainly with markers D11S1377 and D11S933. In order to determine if these positive findings could be replicated in our sample, we undertook a family-based association study in 199 French Canadian TS nuclear families. We genotyped 572 individuals from 174 complete and 25 incomplete TS trios. TDT analysis failed to detect an association between TS and six markers from 11q24. Furthermore, no haplotype combining alleles from D11S1377, D11S933, or any of the other four markers was associated with the disorder. Linkage disequilibrium analysis showed evidence of historical recombination between every contiguous pair of markers, indicating that these genetic variants are probably in equilibrium in the French Canadian population. Further analysis in additional families, with different methodologies (linkage and association) will be required in order to determine if the 11q24 region harbors a susceptibility locus for TS. If it does, this defect may not be frequent in the French Canadian population due to locus heterogeneity.es_ES


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