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Family-based association study between the monoamine oxidase A gene and obesity: implications for psychopharmacogenetic studies

dc.creatorCamarena,Beatriz
dc.creatorAguilar, Alejandro
dc.creatorLoyzaga, Cristina
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-29T04:33:58Z
dc.date.available2017-06-29T04:33:58Z
dc.date.issued2004es_ES
dc.identifier439es_ES
dc.identifier.issn0302-282Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5128
dc.identifier.urihttps://doi.org/10.1159/000076720es_ES
dc.language.isoenges_ES
dc.relation49 (3) 126-129 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleFamily-based association study between the monoamine oxidase A gene and obesity: implications for psychopharmacogenetic studieses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatrıía Ramón de la Fuente, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, México D.F., 14370, Méxicoes_ES
dc.contributor.emailnicolini_humberto@yahoo.comes_ES
dc.relation.jnabreviadoNEUROPSYCHOBIOLOGYes_ES
dc.relation.journalNeuropsychobiologyes_ES
dc.identifier.placeBaseles_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1423-0224es_ES
dc.description.abstractotrodiomaFamily studies have reported that obesity has a strong heritable component. It has been suggested that a neurotransmitter dysfunction could be involved in mental disorders and obesity; therefore, candidate genes in psychiatric disorders could be a risk factor for obesity. We investigated the association between the monoamine oxidase A (MAO-A) gene and obesity. Fifty obese subjects and their parents were included in the study. Two polymorphisms designated EcoRV and upstream variable number tandem repeats of the MAO-A gene were analysed using polymerase chain reaction. For analysis of the families, the transmission disequilibrium test (TDT) was applied. The TDT analysis of the EcoRV polymorphism showed in obese subjects with a body mass index (BMI) >/=35 kg/m(2) a preferential transmission of the low activity-related allele (chi(2)(TDT) = 8.0, p = 0.005). Our findings may provide evidence of a candidate gene involved in obese subjects with a BMI >/=35 kg/m(2).es_ES


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