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A family-based association study of the 5-HT-1Dbeta receptor gene in obsessive-compulsive disorder

dc.creatorCamarena, Beatriz
dc.creatorAguilar, Alejandro
dc.creatorLóyzaga, Cristina
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-29T04:32:55Z
dc.date.available2017-06-29T04:32:55Z
dc.date.issued2004es_ES
dc.identifier427es_ES
dc.identifier.issn1461-1457es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5116
dc.identifier.urihttps://doi.org/10.1017/S1461145703003869es_ES
dc.language.isoenges_ES
dc.relation(7) 49–53 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleA family-based association study of the 5-HT-1Dbeta receptor gene in obsessive-compulsive disorderes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatrıía Ramón de la Fuente, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, México D.F., 14370, Méxicoes_ES
dc.contributor.emailnicolini_humberto@yahoo.comes_ES
dc.relation.jnabreviadoINT J NEUROPSYCHOPHARMACOLes_ES
dc.relation.journalInternational Journal of Neuropsychopharmacologyes_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1017/S1461145703003869es_ES
dc.description.abstractotrodiomaPharmacological studies have shown that sumatriptan, a selective ligand of the serotonin 5-HT-1Db autoreceptor, modifies obsessive–compulsive disorder (OCD) symptoms. The current study analysed the G861C polymorphism of the 5-HT-1Db gene in a sample of 72 trios. Genotyping data were analysed using the Family-Based Association Test (FBAT). We did not replicate the previously reported linkage disequilibrium between the G861 variant and OCD. However, a quantitative trait analysis, assessing severity of OCD symptoms and defined as YBOCS score, confirmed the finding that subjects with a preferentiatransmission of the G861 variant showed higher YBOCS Obsession scores compared to patients carrying the C861 allele. These preliminary findings may indicate that the 5-HT-1Db receptor gene could be involved in the severity of obsession symptoms in OCD. However, it is important to perform the replication of these findings in larger sample sizes of informative families.es_ES
dc.subject.koAssociationes_ES
dc.subject.ko5-HT-1Db receptor genees_ES
dc.subject.koObsessive–compulsive disorderes_ES
dc.subject.koSeverityes_ES
dc.subject.koQuantitative traitses_ES


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