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Effects of melatonin on the nitric oxide treated retina

dc.creatorSiu, A.W.
dc.creatorOrtíz, G.G.
dc.creatorBenítez-King, G.
dc.creatorTo, C.H.
dc.creatorReiter, R.J.
dc.date.accessioned2017-06-29T04:32:24Z
dc.date.available2017-06-29T04:32:24Z
dc.date.issued2004es_ES
dc.identifier421es_ES
dc.identifier.issn0007-1161es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5110
dc.identifier.urihttp://dx.doi.org/10.1136/bjo.2003.037879es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1772281/es_ES
dc.language.isoenges_ES
dc.relation88 (8) 1078-1081 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of melatonin on the nitric oxide treated retinaes_ES
dc.typearticlees_ES
dc.contributor.affiliationDivision de Neurociencias, Centro de Investigacion Biomedica de Occidente (IMSS), Guadalajara, Jalisco, Mexicoes_ES
dc.relation.jnabreviadoBR J OPHTHALMOLes_ES
dc.relation.journalBritish Journal of Ophthalmologyes_ES
dc.identifier.placeLondones_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1136/bjo.2003.037879es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaAims: Nitric oxide (NO) is a free radical which reportedly causes damage to living cells. This study evaluated the damaging effect of NO and the protection of melatonin on the retina in vivo.Methods: Female Wistar rats (230–250 g) received two intraperitoneal injections of either melatonin (5 mg/kg) or vehicle alone. After general anaesthesia, the animals received 1 _l intravitreal injections of 0.9% saline and 1 mM sodium nitroprusside (SNP) into the right eye and the left eye, respectively. The animals were divided into two groups and then sacrificed after 24 hours (day 1) and 96 hours (day 4). The mean inner retinal layer thickness (mIRLT), the number of retinas expressing hyperchromatic (HC) nuclei in the inner nuclear layer (INL) and the apoptotic ganglion cell detection were compared. Results: After 1 day, SNP significantly increased the mIRLT by 45% (p = 0.004), initiated more INL nuclear HC expression (p = 0.01) and apoptotic nuclei (p<0.05) compared with the control eyes. Injection of melatonin ameliorated these changes. On day 4, SNP demonstrated similar effects in all parameters on the retina. After the injection of melatonin, both INL HC expression and apoptotic ganglion nuclei in the SNP treated eyes were similar to the controls but the mIRLT was significantly greater than in controls (p = 0.006). Conclusion: Uncontrolled NO elevation caused morphological and nuclear changes in the retina. Melatonin significantly suppressed the NO induced increase in mIRLT, INL HC expression, and apoptotic ganglion cells on day 1, but not after day 4. Melatonin may have a protective role in the NO elevated retina.es_ES
dc.subject.koMelatonines_ES
dc.subject.koNitric oxidees_ES
dc.subject.koRetinaes_ES
dc.subject.koRabbitses_ES


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