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Comparative study of the effects of toluene, benzene, 1,1,1-trichloroethane, diethyl ether, and flurothyl on anxiety and nociception in mice

dc.creatorPáez-Martínez, Nayeli
dc.creatorCruz, Silvia Lorenia
dc.creatorLópez-Rubalcava, Carolina
dc.date.accessioned2017-06-29T04:31:41Z
dc.date.available2017-06-29T04:31:41Z
dc.date.issued2003es_ES
dc.identifier412es_ES
dc.identifier.issn0041-008Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5102
dc.identifier.urihttps://doi.org/10.1016/S0041-008X(03)00335-1es_ES
dc.language.isoenges_ES
dc.relation193 (1) 9-16 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleComparative study of the effects of toluene, benzene, 1,1,1-trichloroethane, diethyl ether, and flurothyl on anxiety and nociception in micees_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Cinvestav, IPN. Calz. de los Tenorios 235, Col. Granjas Coapa, México D.F. 14330, Méxicoes_ES
dc.contributor.emailclopez@sni.conacyt.mxes_ES
dc.relation.jnabreviadoTOXICOL APPL PHARMACOLes_ES
dc.relation.journalToxicology and Applied Pharmacologyes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/S0041-008X(03)00335-1es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaThe main purpose of this study was to compare the effects of solvents from different chemical classes on anxiety and nociception. Independent groups of mice were exposed to air (control group), toluene (1000–4000 ppm), benzene (1000–4000 ppm), 1,1,1-trichloroethane (TCE, 2000–12000 ppm), diethyl ether (10,000 –30,000) or flurothyl (200–600 ppm). After a 30-min exposure, animals were tested either in the anxiety paradigm conditioned defensive burying (CDB) test or in the hot plate test. All solvents but flurothyl produced anxiolytic-like actions being the order of potency toluene _ benzene _ TCE _ diethyl ether. When tested in the hot plate paradigm, toluene and TCE increased nociception, benzene and diethyl ether had no effects, and flurothyl decreased nociception Additional groups of mice were conditioned to recognize the aversive stimulus (electrified prod) prior to toluene exposure and then tested in the CDB test. In unconditioned animals, toluene increased the number of shocks that mice received; however, when mice had previous experience in the CDB test, toluene lacked this effect. Taken together, these results show that inhalants have different effects with different potencies both in the CDB and in the hot plate tests. Additionally, data suggest that acute administration of toluene could impair learning.es_ES
dc.subject.kwAbuso de inhalanteses_ES
dc.subject.kwAnxioliticos-efectos similareses_ES
dc.subject.kwNocicepciónes_ES
dc.subject.kwPrueba del comportamiento condicionado defensivoes_ES
dc.subject.kwAprendizajees_ES
dc.subject.koInhalant abusees_ES
dc.subject.koAnxiolytic-like effectses_ES
dc.subject.koNociceptiones_ES
dc.subject.koConditioned defensive behavior testes_ES
dc.subject.koLearninges_ES


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