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Minimum effective doses of haloperidol for the treatment of first psychotic episode: a comparative study with risperidone and olanzapine

dc.creatorApiquián, Rogelio
dc.creatorFresán, Ana
dc.creatorHerrera, Karen
dc.creatorUlloa, Rosa Elena
dc.creatorLóyzaga, Cristina
dc.creatorDe la Fuente-Sandoval, Camilo
dc.creatorGutiérrez, Doris
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-29T04:31:25Z
dc.date.available2017-06-29T04:31:25Z
dc.date.issued2003es_ES
dc.identifier409es_ES
dc.identifier.issn1461-1457es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5099
dc.identifier.urihttps://doi.org/10.1017/S1461145703003742es_ES
dc.language.isoenges_ES
dc.relation6 (4) 403-408 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleMinimum effective doses of haloperidol for the treatment of first psychotic episode: a comparative study with risperidone and olanzapinees_ES
dc.typearticlees_ES
dc.contributor.affiliationClinical Research Division, National Institute of Psychiatry 'Ramón de la Fuente', Mexico City, Mexicoes_ES
dc.contributor.emailapiquian@imp.edu.mxes_ES
dc.relation.jnabreviadoINT J NEUROPSYCHOPHARMACOLes_ES
dc.relation.journalThe international journal of neuropsychopharmacologyes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doidoi:10.1017/S1461145703003742es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaMinimum doses of haloperidol might show similar efficacy and side-effects compared to atypical antipsychotics. The objectives of this study were to compare the efficacy of minimum doses of haloperidol with standard doses of risperidone and olanzapine on a 6-month open trial in first psychotic episode patients and to examine the effect of compliance on their outcome. Forty-two patients were recruited and started on flexible doses of these drugs. Olanzapine was given with no cost to the patients. Efficacy and side-effects were monitored every 3 months using standardized assessments. Thirty patients completed the study. All treatment groups showed improvement in positive, negative and depressive symptoms. There were no differences in side-effects among them. The haloperidol group required higher doses of anticholinergics. The rate of treatment discontinuation was higher in the risperidone group due to the direct cost. Minimum doses of haloperidol might prove to be a good choice of treatment for patients with a first episode of psychosises_ES
dc.subject.kwTratamiento antipsicóticoes_ES
dc.subject.kwPrimer episodio psicóticoes_ES
dc.subject.kwDosis mínimases_ES
dc.subject.koAntipsychotic treatmentes_ES
dc.subject.koFirst psychotic episodees_ES
dc.subject.koMinimum doseses_ES


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