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Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder

dc.creatorFernández-Guasti, A.
dc.creatorUlloa, R.E.
dc.creatorNicolini, H.
dc.date.accessioned2017-06-29T04:31:03Z
dc.date.available2017-06-29T04:31:03Z
dc.date.issued2003es_ES
dc.identifier404es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5095
dc.identifier.urihttps://doi.org/10.1007/s00213-002-1301-1es_ES
dc.language.isoenges_ES
dc.relation166 (3) 195-201 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino)tetralines_ES
dc.subject.meshAging-Psychologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive Agents, Tricyclic-Therapeutic usees_ES
dc.subject.meshDesipramine-Pharmacologyes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshMalees_ES
dc.subject.meshObsessive Compulsive Disorder-Drug therapyes_ES
dc.subject.meshPiperazineses_ES
dc.subject.meshPyridineses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, Serotonin-Drug effectses_ES
dc.subject.meshReceptors, Serotonin, 5-HT1es_ES
dc.subject.meshSerotonin Antagonistses_ES
dc.subject.meshSerotonin Receptor Agonistses_ES
dc.subject.meshReceptors, Serotonines_ES
dc.subject.meshSerotonin Antagonistses_ES
dc.subject.meshClomipraminees_ES
dc.subject.meshN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidees_ES
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino)tetralines_ES
dc.titleAge differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorderes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Centro de Investigación y Estudios Avanzados, Calz. De los Tenorios 235, Col. Granjas Coapa, 14330, México D.F., Méxicoes_ES
dc.contributor.emailjfernand@mail.cinvestav.mxes_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.doi10.1007/s00213-002-1301-1es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaRATIONALE: Subtypes of obsessive-compulsive disorder (OCD) related to age could determine differential response to treatment.OBJECTIVES: To explore possible age differences in the effect of clomipramine in an animal model of OCD. METHODS: The deficits on spontaneous alternation produced by 8-OH-DPAT and the preventing actions of clomipramine, desipramine and WAY 100635 were compared between young and adult rats. RESULTS: No age differences were found in spontaneous alternation. The 5-HT(1A) agonist, 8-OH-DPAT (0.031, 0.125, 0.5 and 2.0 mg-kg, -15 min) produced perseveration in young and adult rats. However, young rats were sensitive to a lower dose of 8-OH-DPAT. Clomipramine (10 mg-kg per three administrations) completely prevented the action of 8-OH-DPAT (0.5 mg-kg) in adult rats. However, this treatment as well as higher doses (15 mg-kg 3 administrations) or injected for longer periods (10 mg-kg 5 administrations) produced weak protective effects (versus 0.125 mg-kg 8-OH-DPAT) or had no action (versus 0.5 mg-kg 8-OH-DPAT) in young animals. WAY 100 635 (0.5 mg-kg) blocked the action of 8-OH-DPAT (0.5 mg-kg) in both young and adult rats. Desipramine (10 mg-kg-3 administrations) lacked of a preventive effect on the 8-OH-DPAT (0.5 mg-kg) action. This result indicated that the 5-HT(1A) receptor is involved in the deficits on spontaneous alternation produced by 8-OH-DPAT. CONCLUSIONS: The present data shows important age differences in the effect of clomipramine in a model of OCD. Such differences could be relevant for the age variations in the response to treatment in clinical practicees_ES


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