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Orchidectomy sensitizes male rats to the action of diazepam on burying behavior latency: role of testosterone

dc.creatorFernández-Guasti, Alonso
dc.creatorMartínez-Mota, Lucía
dc.date.accessioned2017-06-29T04:30:51Z
dc.date.available2017-06-29T04:30:51Z
dc.date.issued2003es_ES
dc.identifier402es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/S0091-3057(03)00142-4es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5093
dc.identifier.urihttps://doi.org/10.1016/S0091-3057(03)00142-4es_ES
dc.language.isoenges_ES
dc.relation75 (2) 473-479 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.meshAnxiety-Psychologyes_ES
dc.subject.meshDiazepam-Pharmacologyes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshInjections, Intraperitoneales_ES
dc.subject.meshMalees_ES
dc.subject.meshMotor Activity-Drug effectses_ES
dc.subject.meshOrchiectomyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshTestosterone-Pharmacologyes_ES
dc.subject.meshTestosterone-Physiologyes_ES
dc.subject.meshAnti-Anxiety Agentses_ES
dc.subject.meshDiazepames_ES
dc.subject.meshTestosteronees_ES
dc.titleOrchidectomy sensitizes male rats to the action of diazepam on burying behavior latency: role of testosteronees_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del IPN, Calzada de los Tenorios 235, Col. Granjas Coapa, Mexico 14330 DF, Mexico.es_ES
dc.contributor.emailjfernand@mail.cinvestav.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology, Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/S0091-3057(03)00142-4es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaThe anxiolytic-like effect of diazepam (0.0, 0.5, 1.0 mg-kg) on the cumulative burying behavior and the burying behavior latency were compared between intact and castrated male rats. In both groups a clear reduction in cumulative burying, denoting an anxiolytic-like response, was observed. However, castrated males were more sensitive to diazepam in the burying behavior latency, a parameter indicating reactivity. Thus, orchidectomized males showed an increase in burying behavior latency after 1.0 mg-kg diazepam treatment. This dose has no effect on burying behavior latency in intact animals. The higher sensitivity to diazepam on reactivity seems to be androgen dependent because it was reversed by chronic treatment with testosterone propionate (TP, 0.0625 mg-rat for 2 weeks). TP (0.0, 0.0625, 0.125, 0.25, 0.5 and 1.0 mg-rat) produced a dose-dependent reduction in burying behavior after chronic treatment (four injections separated 48 h). At no dose did TP affect burying behavior latency. These results indicate that some actions of diazepam vary in males depending upon the endocrine milieu. Results also support the idea of androgens possessing anxiolytic-like actionses_ES


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