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Acute ethanol administration transiently decreases [3H]-DAMGO binding to mu opioid receptors in the rat substantia nigra pars reticulata but not in the caudate-putamen

dc.creatorMéndez, M.
dc.creatorLeriche, M.
dc.creatorCarlos Calva, J.
dc.date.accessioned2017-06-29T04:30:46Z
dc.date.available2017-06-29T04:30:46Z
dc.date.issued2003es_ES
dc.identifier401es_ES
dc.identifier.issn0168-0102es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5092
dc.identifier.urihttps://doi.org/10.1016/S0168-0102(03)00188-3es_ES
dc.language.isoenges_ES
dc.relation47 (2) 153-160 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAcute ethanol administration transiently decreases [3H]-DAMGO binding to mu opioid receptors in the rat substantia nigra pars reticulata but not in the caudate-putamenes_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Subdirección de Investigaciones Clínicas, Calzada México Xochimilco 101, Col. San Lorenzo Huipulco, 14370, Mexico D F, Méxicoes_ES
dc.contributor.emailubach@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROSCI RESes_ES
dc.relation.journalNeuroscience researches_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaEthanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and/or receptor binding of opioid peptides. We studied the effects of a single acute dose of ethanol on rat nigrostriatal mu opioid receptors by quantitative receptor autoradiography, using [3H] [D-Ala(2),MePhe(4),Gly-ol(5)]-enkephalin ([3H]-DAMGO) as radioligand. [3H]-DAMGO binding was significantly decreased in the pars reticulata of the substantia nigra 1 h after ethanol administration. Ethanol exposure did not affect [3H]-DAMGO binding neither in the pars compacta of the substantia nigra nor in the caudate-putamen at any time tested after drug administration. The observed effects may reflect ethanol-induced changes in ligand binding affinity (Kd) or in receptor density (Bmax). Early and transitory ethanol-induced changes of mu receptors in the substantia nigra pars reticulata may be related to regulation of dopaminergic nigrostriatal transmission and contribute to determine brain sensitivity to the drug.es_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmCaudate Nucleus-Drug effectses_ES
dc.subject.meshmCaudate Nucleus-Metabolismes_ES
dc.subject.meshmEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Metabolismes_ES
dc.subject.meshmEthanol-Administration & dosagees_ES
dc.subject.meshmMalees_ES
dc.subject.meshmProtein Binding-Drug effectses_ES
dc.subject.meshmProtein Binding-Physiologyes_ES
dc.subject.meshmPutamen-Drug effectses_ES
dc.subject.meshmPutamen-Metabolismes_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRaats, Wistares_ES
dc.subject.meshmReceptors, Opioid mu-Metabolismes_ES
dc.subject.meshmSubstantia Nigra-Drug effectses_ES
dc.subject.meshmSubstantia Nigra-MEtabolismes_ES
dc.subject.meshmTritium-Metabolismes_ES


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