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Actions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activities

dc.creatorCondés-Lara, Miguel
dc.creatorGonzález, Nephtali Marina
dc.creatorMartínez-Lorenzana, Guadalupe
dc.creatorLuis Delgado, Oliva
dc.creatorFreund-Mercier, Marie José
dc.date.accessioned2017-06-29T04:29:44Z
dc.date.available2017-06-29T04:29:44Z
dc.date.issued2003es_ES
dc.identifier388es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5079
dc.identifier.urihttps://doi.org/10.1016/S0006-8993(03)02690-8es_ES
dc.language.isoenges_ES
dc.relation976 (1) 75-81 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshSensory systemses_ES
dc.subject.meshAnatomia y fisiologíaes_ES
dc.subject.meshModulación del dolores_ES
dc.titleActions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activitieses_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, México; Instituto Nacional de Psiquiatría, México D.F., Méxicoes_ES
dc.contributor.emailcondes@servidor.unam.mxes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaAmong the numerous pain control mechanisms that have been proposed, those acting at the spinal cord have been broadly studied, but little is known about how neuropeptides originating in supraspinal structures may relate to pain and analgesic mechanisms. Oxytocin (OT), in addition to its well known hormonal action, produces neuronal effects in various regions of the central nervous system. Indeed, some parvocellular neurons in the hypothalamic paraventricular nucleus (PVN) are oxytocinergic and project to the caudal part of the brain and the spinal cord. Moreover, the rat spinal cord shows a good overlap between the oxytocinergic hypothalamo-spinal neuron projections and the distribution of OT binding sites. However, the physiological significance of these binding sites is largely unknown. Extracellular unit activity of spinal cord neurons was recorded at the T13–L1 levels in male rats anesthetized with halotane. Somatic stimulation was applied to the inner and outer thigh of the ipsilateral hindpaw, and glutamate (GLU) and OT were locally delivered by pressure using pipettes coupled to recording electrodes. Our results show that spinal cord neurons, mainly located in the dorsal horn, in the intermediolateral cell column (IML) and in the intermediomedial gray matter (IMM), respond to the application of OT (71.5%) with activation (48%) or inhibition (52%). In some cases, opposite OT effects were observed during simultaneous recordings of two cells, suggesting OT activation of an inhibitory interneuron followed by the inhibition of the second recorded neuron. Increases in neuronal firing rate produced by GLU could be blocked by prior OT application. Finally, OT could reduce or partially block the responses to tactile and nociceptive somatic stimulation. We found that spinal cord neurons are sensitive to OT indicating that OT binding sites are functionally active. OT effects suggest the activation of inhibitory interneurons acting on a second order projecting cells to modulate afferent tactile and nociceptive informationes_ES
dc.subject.meshmAnatomy and physiologyes_ES
dc.subject.meshmPain modulationes_ES
dc.subject.kwDolor y analgesiaes_ES
dc.subject.kwModulación sensoriales_ES
dc.subject.kwTransmisión sináptica y excitabilidades_ES
dc.subject.kwOxitocinaes_ES
dc.subject.koPain and analgesiaes_ES
dc.subject.koSensorial modulationes_ES
dc.subject.koSynaptic transmission and excitabilityes_ES
dc.subject.koOxytocines_ES


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