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Effects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-D-aspartic acid in mice

dc.creatorCruz, Silvia Lorenia
dc.creatorGauthereau, Marcia Yvette
dc.creatorCamacho-Muñoz, Cynthia
dc.creatorLópez-Rubalcava, Carolina
dc.creatorBalster, Robert L.
dc.date.accessioned2017-06-29T04:29:29Z
dc.date.available2017-06-29T04:29:29Z
dc.date.issued2003es_ES
dc.identifier385es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5076
dc.identifier.urihttps://doi.org/10.1016/S0166-4328(02)00323-6es_ES
dc.language.isoenges_ES
dc.relation140 (1-2) 195-202 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-D-aspartic acid in micees_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Cinvestav, IPN. Calzada de los Tenorios #235, Col. Granjas Coapa, 14330 México, D.F., Méxicoes_ES
dc.contributor.emailcruz_farma@yahoo.comes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaEvidence exists that some abused solvents have N-methyl-D-aspartic acid (NMDA) antagonist activity, although which of their effects may be related to this mechanism is not well understood. The effects of toluene and 1,1,1-trichloroethane (TCE) on NMDAinduced seizures in mice were studied using three experimental protocols: (a) animals injected i.p. with 120 or 170 mg/kg NMDA and immediately afterwards exposed to solvent vapors or air for 30 min (co-exposure protocol); (b) mice exposed for 30 min to solvent or air, then injected with NMDA and placed in the chamber for a second 30-min exposure (pre-exposure_/co-exposure protocol); and (c) mice that inhaled 4000 ppm toluene or air for 30 min twice a day, 6 h apart, for 7 days, and were injected with 120 mg/kg NMDA immediately before a 30-min toluene exposure (repeated exposure protocol). When given acutely, toluene, but not TCE, produced concentration-dependent protection against NMDA-induced seizures. Higher concentrations of toluene were also effective against the lethal effects produced by 170 mg/kg NMDA. Clearer effects were seen when the pre-exposure_/co-exposure protocol was followed. Under these conditions the IC50 for toluene was 739 ppm (653_/825) against seizure occurrence and 2127 ppm (1966_/2288) against lethality. Repeated exposure to toluene did not result in tolerance to its anticonvulsant effects. These results are consistent with the in vitro effects described for toluene as a noncompetitive NMDA antagonist and as a compound that enhances GABAergic transmission. The lack of protective effects of TCE is not consistent with its in vitro actions.es_ES
dc.subject.kwToluenoes_ES
dc.subject.kwTricloroetanoes_ES
dc.subject.kwabuso de inhalanteses_ES
dc.subject.kwNMDAes_ES
dc.subject.kwabuso de drogases_ES
dc.subject.kwconvulsioneses_ES
dc.subject.koToluenees_ES
dc.subject.koTrichloroethanees_ES
dc.subject.koInhalant abusees_ES
dc.subject.koSeizureses_ES
dc.subject.koNMDAes_ES
dc.subject.koDrug abusees_ES


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