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Efficacy of metadoxine in the management of acute alcohol intoxication

dc.creatorDíaz Martínez, M.C.
dc.creatorDíaz Martínez, A.
dc.creatorVillamil Salcedo, V.
dc.creatorCruz Fuentes, C.
dc.date.accessioned2017-06-29T04:29:05Z
dc.date.available2017-06-29T04:29:05Z
dc.date.issued2002es_ES
dc.identifier380es_ES
dc.identifier.issn0300-0605es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5071
dc.identifier.urihttps://doi.org/10.1177/147323000203000107es_ES
dc.language.isoenges_ES
dc.relation30 (1) 44-51 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdultes_ES
dc.subject.meshAlcohol Deterrentses_ES
dc.subject.meshTherapeutic Usees_ES
dc.subject.meshAlcoholic Intoxicationes_ES
dc.subject.meshBloodes_ES
dc.subject.meshDrug Therapyes_ES
dc.subject.meshPhysiopathologyes_ES
dc.subject.meshCentral Nervous Systemes_ES
dc.subject.meshDrug Effectses_ES
dc.subject.meshDrug Combinationses_ES
dc.subject.meshEthanoles_ES
dc.subject.meshBloodes_ES
dc.subject.meshFemalees_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshPyridoxinees_ES
dc.subject.meshTherapeutic Usees_ES
dc.subject.meshPyrrolidonecarboxylic Acides_ES
dc.subject.meshTherapeutic Usees_ES
dc.titleEfficacy of metadoxine in the management of acute alcohol intoxicationes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Medical Psychology, Psychiatry and Mental Health, School of Medicine, University of Mexico, Toxicological Unit Xochimilco, Mexico City, Mexicoes_ES
dc.contributor.emailleonydiaz@hotmail.comes_ES
dc.relation.jnabreviadoJ INT MED RESes_ES
dc.relation.journalThe Journal of international medical researches_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2002es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthEne-Febes_ES
dc.description.abstractotrodiomaThis randomized, open-label study evaluated the efficacy of 300 mg metadoxine (given intravenously) added to standard treatment compared with standard treatment alone in managing the physical and psychological signs of acute alcohol intoxication. Fifty-two acutely intoxicated patients were randomly assigned to one of two groups and followed during a 2-h period. Changes in clinical symptoms, degree of intoxication, and blood alcohol level were monitored. More patients receiving metadoxine in addition to standard therapy significantly improved by at least one degree of intoxication (one clinical category) compared with those receiving standard treatment alone (76.9% versus 42.3%, respectively). Metadoxine-treated patients also exhibited a significantly greater decrease in blood alcohol concentration compared with those receiving standard treatment alone (-105.4 +/- 61.5 mg/dl versus -60.1 +/- 38.6 mg/dl, respectively). Metadoxine improved the clinical signs of acute alcohol intoxication and accelerated alcohol clearance from the blood, thus supporting existing data. In contrast to previous data, these effects were concurrent but independent. No adverse effects were observed with metadoxine therapyes_ES


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