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Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors

dc.creatorMartínez-Mota, Lucía
dc.creatorEstrada-Camarena, Erika
dc.creatorLópez-Rubalcava, Carolina
dc.date.accessioned2017-06-29T04:28:20Z
dc.date.available2017-06-29T04:28:20Z
dc.date.issued2002es_ES
dc.identifier370es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5061
dc.identifier.urihttps://doi.org/10.1007/s00213-002-1222-zes_ES
dc.language.isoenges_ES
dc.relation165 (1) 60-66 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.mesh5-Methoxytryptamine-Analogs & derivativeses_ES
dc.subject.mesh5-Methoxytryptamine-Pharmacologyes_ES
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino)tetralin-Pharmacologyes_ES
dc.subject.meshAnalysis of Variancees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive Agents-Pharmacologyes_ES
dc.subject.meshBehavior, Animales_ES
dc.subject.meshDrug effectses_ES
dc.subject.meshBenzamides-Pharmacologyes_ES
dc.subject.meshBuspirone-Pharmacologyes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshDrug Interactionses_ES
dc.subject.meshKetanserin-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMotor Activity-Drug effectses_ES
dc.subject.meshMotor Activity-Physiologyes_ES
dc.subject.meshPindolol-Pharmacologyes_ES
dc.subject.meshPyridines-Pharmacologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, Serotonin-Drug effectses_ES
dc.subject.meshReceptors, Serotonin-Physiologyes_ES
dc.subject.meshReceptors, Serotonin, 5-HT1es_ES
dc.subject.meshSerotonin Antagonists-Pharmacologyes_ES
dc.subject.meshSerotonin Receptor Agonists-Pharmacologyes_ES
dc.subject.meshSwimming-Physiologyes_ES
dc.subject.meshSwimming-Psychologyes_ES
dc.subject.meshAntidepressive Agentses_ES
dc.subject.meshBenzamideses_ES
dc.subject.meshPyridineses_ES
dc.subject.meshReceptors, Serotonines_ES
dc.subject.meshSerotonin Antagonistses_ES
dc.subject.meshSerotonin Receptor Agonistses_ES
dc.subject.meshPindololes_ES
dc.subject.mesh3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamidees_ES
dc.subject.meshBuspironees_ES
dc.subject.mesh5-Methoxytryptaminees_ES
dc.subject.meshKetanserines_ES
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino)tetralines_ES
dc.subject.meshIndorenatees_ES
dc.titleIndorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptorses_ES
dc.typearticlees_ES
dc.contributor.affiliationSubdirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, México 14370, D.F.es_ES
dc.contributor.emaillucia@imp.edu.mxes_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published2002es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.doi10.1007/s00213-002-1222-zes_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaRationale. Indorenate has been proposed to possess antihypertensive, anorectic, stimulus control and anxiolytic-like actions. This compound has affinity mainly for the serotonergic1A-1B receptors, hence it could possess antidepressant-like activity. Objectives. The general purpose of this study was to explore the possible antidepressant-like effects of the serotonergic compound indorenate in the forced swimming test (FST). Methods. In a first approach, a comparison of the actions of several doses of indorenate (2.5, 5.0, 10 mg-kg) with those of other 5-HT1A agonists, buspirone (5.0, 10.0 mg-kg) and 8-OH-DPAT (0.25, 0.50, 1.0 mg-kg), was performed in the FST. Secondly, in order to determine the serotonergic receptors that are participating in indorenate's action, different doses of serotonergic antagonists were administered. The compounds used were the 5-HT1A-1B and _-adrenergic antagonist pindolol (2.5, 5.0 mg-kg), the 5-HT1B receptor antagonist GR 55562 (0.75, 1.5, 3.0 mg-kg), the 5-HT1A antagonist WAY 100635 (0.25, 0.5, 1.0 mg-kg) and the 5-HT2 antagonist ketanserin (1.0, 2.0, 4.0 mg-kg). Results. Indorenate (10 mg-kg), 8-OH-DPAT (1.0 mg-kg) and buspirone (5.0 and 10.0 mg-kg) reduced immobility behaviour in the FST, considered as an antidepressant-like effect. Both doses of pindolol (2.5 and 5.0 mg-kg) and WAY 100635 (0.5 and 1.0 mg-kg) antagonised the antidepressant-like effect of indorenate. Neither 5-HT1B (GR55562) nor 5-HT2 (ketanserin) antagonists produced changes in the effect of indorenate in the FST. Conclusions. Indorenate produces antidepressant-like actions in the FST that are mediated by the stimulation of 5-HT1A receptorses_ES
dc.subject.kw5-metoxitriptamina-Análogos y derivadoses_ES
dc.subject.kw5-metoxitriptamina-Farmacologíaes_ES
dc.subject.kw8-hidroxi-2-(di-n-propilamino) tetralina-Farmacologíaes_ES
dc.subject.kwAnálisis de varianzaes_ES
dc.subject.kwAgentes antidepresivos-Farmacologíaes_ES
dc.subject.kwAnimaleses_ES
dc.subject.kwEfectos del fármacoes_ES
dc.subject.kwBenzamidas-Farmacologíaes_ES
dc.subject.kwBuspirona-Farmacologíaes_ES
dc.subject.kwDosis-Respuesta a Drogaes_ES
dc.subject.kwInteracciones medicamentosases_ES
dc.subject.kwKetanserina-Farmacologíaes_ES
dc.subject.kwMasculinoes_ES
dc.subject.kwActividad motora-Efectos de Drogases_ES
dc.subject.kwActividad Motora-Fisiologíaes_ES
dc.subject.kwPindolol-Farmacologíaes_ES
dc.subject.kwPiridinas-Farmacologíaes_ES
dc.subject.kwRatases_ES
dc.subject.kwRatas Wistares_ES
dc.subject.kwReceptores de Serotonina-Fisiologíaes_ES
dc.subject.kwAntagonistas de la Serotonina-Farmacologíaes_ES
dc.subject.kwAgonistas del Receptor de Serotonina-Farmacologíaes_ES
dc.subject.kwNatación-Fisiologíaes_ES
dc.subject.kwNatación-Psicologíaes_ES
dc.subject.kwAgentes antidepresivoses_ES
dc.subject.kwBenzamidases_ES
dc.subject.kwPiridinases_ES
dc.subject.kwReceptores de Serotoninaes_ES
dc.subject.kwAntagonistas de la Serotoninaes_ES
dc.subject.kwSerotonina Agonistas del receptores_ES
dc.subject.kwPindololes_ES
dc.subject.kw3 - (3 - (dimetilamino) propil)-4-hidroxi-N-(4 - (4-piridinil) fenil) benzamidaes_ES
dc.subject.kwBuspironaes_ES
dc.subject.kw5-metoxitriptaminaes_ES
dc.subject.kwKetanserinaes_ES
dc.subject.kw8-hidroxi-2-(di-n-propilamino) tetralinaes_ES
dc.subject.kwIndorrenatoes_ES


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