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Chronic ingestion of ethanol or glucose solutions affects hypothalamic and limbic TRH metabolism in dams and their pups

dc.creatorDe Gortari, P.
dc.creatorCisneros, M.
dc.creatorMedellín, M.A.
dc.creatorJoseph-Bravo, P.
dc.date.accessioned2017-06-29T04:28:08Z
dc.date.available2017-06-29T04:28:08Z
dc.date.issued2002es_ES
dc.identifier368es_ES
dc.identifier.issn0197-0186es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/S0197-0186(02)00017-7es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5059
dc.language.isoenges_ES
dc.relation41 (4) 237-249 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBody Weightes_ES
dc.subject.meshEthanol-Administration & dosagees_ES
dc.subject.meshEthanol-Pharmacologyes_ES
dc.subject.meshFemalees_ES
dc.subject.meshGlucose-Administration & dosagees_ES
dc.subject.meshGlucose-Pharmacologyes_ES
dc.subject.meshHypothalamus-Cytologyes_ES
dc.subject.meshHypothalamus-Drug effectses_ES
dc.subject.meshHypothalamus-Metabolismes_ES
dc.subject.meshLimbic System-Cytologyes_ES
dc.subject.meshLimbic System-Drug effectses_ES
dc.subject.meshLimbic System-Metabolismes_ES
dc.subject.meshMalees_ES
dc.subject.meshNeurons-Metabolismes_ES
dc.subject.meshPregnancyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshThyrotropin-Releasing Hormone-Metabolismes_ES
dc.subject.meshThyrotropin-Releasing Hormonees_ES
dc.subject.meshGlucosees_ES
dc.subject.meshEthanoles_ES
dc.titleChronic ingestion of ethanol or glucose solutions affects hypothalamic and limbic TRH metabolism in dams and their pupses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepart. of Neuroscience, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco #101, San Lorenzo Huipulco, Mexico D.F. 14370, Mexico.es_ES
dc.contributor.emailgortari@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROCHEM INTes_ES
dc.relation.journalNeurochemistry Internationales_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2002es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-9754es_ES
dc.identifier.doi10.1016/S0197-0186(02)00017-7es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaThe effect of chronic ethanol consumption during pregnancy and lactation on thyrotropin releasing hormone (TRH) metabolism was investigated in the hypothalamus and limbic areas of female rats and their weaned pups. Pregnant female rats received ethanol or isocaloric glucose solution during pregnancy either alone, or also during the 3 weeks of lactation. Thyrotropin (TSH) and corticosterone levels were measured in serum; TRH and TRH-gly concentrations were determined in hypothalamus, hippocampus, n.accumbens, frontal cortex and amygdala of dams and pups at 21 days after parturition. Ethanol or glucose consumption during pregnancy and lactation produced a decrease in TSH levels compared with control animals fed at libitum; water replacement during lactation normalized TSH levels only in glucose-fed dams. Pups from ethanol or pair-fed dams showed low weight and increased TSH levels compared with normal rats. Variations in TRH metabolism were detected in limbic areas. Chronic ethanol caused a decrease in the levels of TRH in the hippocampus and frontal cortex of dams. In contrast, glucose chronic ingestion increased TRH content specifically in n.accumbens and amygdala of dams. Most of the variations in TRH content of limbic areas of pups were not specific for glucose or ethanol treatment and correlated with the deleterious effect of the mother’s thyroid condition, although some differences were observed depending on pup’s gender. These results support the involvement of TRHergic neurons in the limbic system of the female rat exposed to alcohol or glucose during pregnancy and lactationes_ES


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